Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1033 | 0.6353 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1033 | 0.6353 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1033 | 0.6353 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1033 | 0.6353 | 0.5788 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1033 | 0.6353 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1033 | 0.6353 | 0.9545 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1033 | 0.6353 | 0.9545 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1509 | 1 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0902 | 0.5352 | 0.9089 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1443 | 0.9488 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1443 | 0.9488 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1443 | 0.9488 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0471 | 0.2046 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0894 | 0.5284 | 0.7519 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0775 | 0.4378 | 0.7358 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1033 | 0.6353 | 0.5788 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1509 | 1 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.1033 | 0.6353 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0471 | 0.2046 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1033 | 0.6353 | 0.5 |
Onchocerca volvulus | 0.0203 | 0 | 0.5 | |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0969 | 0.5864 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1033 | 0.6353 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1443 | 0.9488 | 1 |
Onchocerca volvulus | Putative sulfate transporter | 0.0203 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.106 | 0.6558 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.