Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0096 | 0.0937 | 0.0937 |
Trypanosoma brucei | N-myristoyltransferase | 0.0401 | 0.5241 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0145 | 0.0145 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0087 | 0.0087 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0096 | 0.0937 | 0.0937 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0096 | 0.0096 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0401 | 0.5241 | 0.5241 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 0.0096 | 0.0096 |
Brugia malayi | jmjC domain containing protein | 0.0096 | 0.0937 | 0.1788 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0401 | 0.5241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1699 | 0.3242 |
Echinococcus multilocularis | muscleblind protein 1 | 0.015 | 0.1699 | 0.1699 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0401 | 0.5241 | 1 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0096 | 0.0184 |
Brugia malayi | Inositol-1 | 0.004 | 0.0145 | 0.0277 |
Echinococcus granulosus | muscleblind protein | 0.015 | 0.1699 | 0.1699 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0401 | 0.5241 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0264 | 0.3302 | 0.6195 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0035 | 0.0087 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1982 | 0.1982 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0145 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.012 | 0.1275 | 0.2433 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0145 | 0.0145 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0035 | 0.0087 | 0.0087 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0035 | 0.0087 | 0.0087 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0161 | 0.0161 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0739 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.012 | 0.1275 | 0.2433 |
Schistosoma mansoni | jumonji domain containing protein | 0.0076 | 0.066 | 0.066 |
Echinococcus multilocularis | muscleblind protein | 0.015 | 0.1699 | 0.1699 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0096 | 0.0096 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0401 | 0.5241 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0161 | 0.0161 |
Echinococcus granulosus | geminin | 0.017 | 0.1982 | 0.1982 |
Brugia malayi | Muscleblind-like protein | 0.015 | 0.1699 | 0.3242 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0145 | 0.0145 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.1982 | 0.1982 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0145 | 0.0095 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0145 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.006 | 0.0439 | 0.0837 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0401 | 0.5241 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0.1699 | 0.3242 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0401 | 0.5241 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0145 | 0.0277 |
Onchocerca volvulus | Alhambra homolog | 0.0029 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.017 | 0.1982 | 0.1982 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0294 | 0.0562 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0145 | 0.0145 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0401 | 0.5241 | 1 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0401 | 0.5241 | 0.5241 |
Leishmania major | N-myristoyl transferase, putative | 0.0401 | 0.5241 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 0.0096 | 0.0096 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0401 | 0.5241 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0035 | 0.0087 | 0.0165 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0145 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.012 | 0.1275 | 0.2433 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0035 | 0.0087 | 0.0087 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0739 | 1 | 1 |
Schistosoma mansoni | N-myristoyltransferase | 0.0401 | 0.5241 | 0.5241 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0035 | 0.0087 | 0.5 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0035 | 0.0087 | 0.0165 |
Brugia malayi | N-myristoyltransferase 2 | 0.0401 | 0.5241 | 1 |
Giardia lamblia | CDC72 | 0.0401 | 0.5241 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.