Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | breast cancer 1, early onset | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.007 | 0.338 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.0012 | 0.0007 | 0.0358 |
Giardia lamblia | Replication factor C, subunit 1 | 0.0012 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0007 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.0103 | 0.4963 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.0208 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.0012 | 0.0007 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.007 | 0.2331 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.007 | 0.2331 |
Echinococcus granulosus | replication factor c subunit 1 | 0.0012 | 0.0007 | 0.0247 |
Echinococcus multilocularis | geminin | 0.0166 | 0.0301 | 1 |
Wolbachia endosymbiont of Brugia malayi | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.5258 | 1 | 1 |
Schistosoma mansoni | topbp1 | 0.0012 | 0.0007 | 0.0247 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.0012 | 0.0007 | 0.0247 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Brugia malayi | DKFZp564C0469 protein | 0.0012 | 0.0007 | 0.0358 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.0208 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0012 | 0.0007 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0012 | 0.0007 | 0.5 |
Echinococcus granulosus | geminin | 0.0166 | 0.0301 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.0103 | 0.4963 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0012 | 0.0007 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0103 | 0.3423 |
Onchocerca volvulus | 0.0012 | 0.0007 | 0.5 | |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.0012 | 0.0007 | 0.5 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0012 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.0103 | 0.4963 |
Brugia malayi | RNA binding protein | 0.0062 | 0.0103 | 0.4963 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.0103 | 0.4963 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.0007 | 0.5 |
Echinococcus granulosus | nibrin | 0.0012 | 0.0007 | 0.0247 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.5258 | 1 | 1 |
Brugia malayi | topoisomerase | 0.0012 | 0.0007 | 0.0358 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0012 | 0.0007 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.0103 | 0.3423 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0007 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.0103 | 0.3423 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.0103 | 0.4963 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0301 | 1 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.0012 | 0.0007 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0103 | 0.3423 |
Echinococcus multilocularis | nibrin | 0.0012 | 0.0007 | 0.0247 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.5258 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0103 | 0.3423 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.0012 | 0.0007 | 0.5 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.0012 | 0.0007 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0007 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.007 | 0.2331 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.0012 | 0.0007 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.5258 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0007 | 0.5 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras | 0.3152 | 0.599 | 0.5 |
Brugia malayi | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Treponema pallidum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.5258 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0103 | 0.3423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.007 | 0.2331 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.0301 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.0208 | 1 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.0012 | 0.0007 | 0.0247 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.0012 | 0.0007 | 0.0358 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.007 | 0.338 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS | 0.5258 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.007 | 0.2331 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.0103 | 0.3423 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.007 | 0.2331 |
Toxoplasma gondii | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.5258 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0007 | 0.0358 |
Schistosoma mansoni | topbp1 | 0.0012 | 0.0007 | 0.0247 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0012 | 0.0007 | 0.5 |
Schistosoma mansoni | DNA ligase IV | 0.0012 | 0.0007 | 0.0247 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.007 | 0.2331 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.8526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 6.3096 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5878 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 37.933 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.