Detailed information for compound 782588

Basic information

Technical information
  • TDR Targets ID: 782588
  • Name: N-(3-ethylphenyl)-2-(2-oxo-1,3-benzothiazol-3 -yl)acetamide
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1)NC(=O)Cn1c(=O)sc2c1cccc2
  • InChi: 1S/C17H16N2O2S/c1-2-12-6-5-7-13(10-12)18-16(20)11-19-14-8-3-4-9-15(14)22-17(19)21/h3-10H,2,11H2,1H3,(H,18,20)
  • InChiKey: FFKQKHFUUQVZCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-ethylphenyl)-2-(2-keto-1,3-benzothiazol-3-yl)acetamide
  • N-(3-ethylphenyl)-2-(2-oxo-1,3-benzothiazol-3-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cpg binding protein 0.003 0.0064 0.0578
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0602
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.01 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.01 0.0952
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Trichomonas vaginalis helicase, putative 0.0006 0.0006 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.01 0.4054
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.4035 1 1
Schistosoma mansoni hypothetical protein 0.0066 0.0155 0.1569
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0017 0.0104
Echinococcus granulosus geminin 0.0165 0.0399 0.4007
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0051 0.5
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.01 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0231 1
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.4035 1 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0602
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0007 0.0074
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.01 0.4061
Loa Loa (eye worm) hypothetical protein 0.0066 0.0155 0.6524
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0017 0.0104
Loa Loa (eye worm) hypothetical protein 0.0031 0.0066 0.249
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0231 1
Schistosoma mansoni hypothetical protein 0.0401 0.0985 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.006 0.2202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Schistosoma mansoni cpg binding protein 0.003 0.0064 0.0648
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.01 0.0952
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0066 0.2499
Brugia malayi hypothetical protein 0.0016 0.003 0.0832
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0177
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.1812
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.01 0.102
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.0985 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0122 0.0071
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0066 0.2499
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0066 0.249
Schistosoma mansoni cpg binding protein 0.0028 0.006 0.0608
Schistosoma mansoni hypothetical protein 0.0165 0.0399 0.4052
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0051 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0602
Echinococcus granulosus dnaJ subfamily B 0.0401 0.0985 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.006 0.2212
Schistosoma mansoni hypothetical protein 0.0165 0.0399 0.4052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Echinococcus granulosus cpg binding protein 0.003 0.0064 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Echinococcus multilocularis GPCR, family 2 0.0031 0.0066 0.0602
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 0.5
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.4035 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0138 0.1403
Schistosoma mansoni cpg binding protein 0.003 0.0064 0.0648
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0602
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.3185 0.789 0.5
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0051 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.01 0.102
Echinococcus granulosus GPCR family 2 0.0031 0.0066 0.0602
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0231 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.0231 1
Leishmania major hypothetical protein, conserved 0.0025 0.0051 0.5
Brugia malayi hypothetical protein 0.0025 0.0051 0.1822
Onchocerca volvulus 0.0028 0.006 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.01 0.102
Echinococcus multilocularis geminin 0.0165 0.0399 0.4007
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0155 0.6528
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0044

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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