Detailed information for compound 782588

Basic information

Technical information
  • TDR Targets ID: 782588
  • Name: N-(3-ethylphenyl)-2-(2-oxo-1,3-benzothiazol-3 -yl)acetamide
  • MW: 312.386 | Formula: C17H16N2O2S
  • H donors: 1 H acceptors: 2 LogP: 3.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1cccc(c1)NC(=O)Cn1c(=O)sc2c1cccc2
  • InChi: 1S/C17H16N2O2S/c1-2-12-6-5-7-13(10-12)18-16(20)11-19-14-8-3-4-9-15(14)22-17(19)21/h3-10H,2,11H2,1H3,(H,18,20)
  • InChiKey: FFKQKHFUUQVZCP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-ethylphenyl)-2-(2-keto-1,3-benzothiazol-3-yl)acetamide
  • N-(3-ethylphenyl)-2-(2-oxo-1,3-benzothiazol-3-yl)ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0066 0.2499
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.1812
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.01 0.0952
Schistosoma mansoni hypothetical protein 0.0165 0.0399 0.4052
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0066 0.249
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0051 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.01 0.102
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.01 0.0952
Schistosoma mansoni hypothetical protein 0.0165 0.0399 0.4052
Echinococcus granulosus geminin 0.0165 0.0399 0.4007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0044
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Brugia malayi hypothetical protein 0.0025 0.0051 0.1822
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0051 0.5
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0017 0.0104
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0066 0.249
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0051 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.01 0.0952
Schistosoma mansoni hypothetical protein 0.0066 0.0155 0.1569
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0155 0.6528
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0602
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0012 0.0044
Brugia malayi CXXC zinc finger family protein 0.0028 0.006 0.2212
Echinococcus granulosus GPCR family 2 0.0031 0.0066 0.0602
Schistosoma mansoni hypothetical protein 0.0011 0.0017 0.0177
Loa Loa (eye worm) hypothetical protein 0.0097 0.0231 1
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0138 0.1403
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0007 0.0074
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.0985 1
Echinococcus granulosus dnaJ subfamily B 0.0401 0.0985 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.01 0.102
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0231 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0066 0.0602
Loa Loa (eye worm) hypothetical protein 0.0066 0.0155 0.6524
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Echinococcus multilocularis cpg binding protein 0.003 0.0064 0.0578
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.01 0.4054
Echinococcus granulosus cpg binding protein 0.003 0.0064 0.0578
Trichomonas vaginalis helicase, putative 0.0006 0.0006 0.5
Onchocerca volvulus 0.0028 0.006 0.5
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.01 0.102
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0231 1
Schistosoma mansoni cpg binding protein 0.003 0.0064 0.0648
Schistosoma mansoni cpg binding protein 0.0028 0.006 0.0608
Schistosoma mansoni hypothetical protein 0.0401 0.0985 1
Echinococcus multilocularis geminin 0.0165 0.0399 0.4007
Schistosoma mansoni cpg binding protein 0.003 0.0064 0.0648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.01 0.4061
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0231 1
Brugia malayi hypothetical protein 0.0016 0.003 0.0832
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.4035 1 0.5
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.4035 1 1
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.3185 0.789 0.5
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.006 0.2202
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0006 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.01 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0006 0.5
Leishmania major hypothetical protein, conserved 0.0025 0.0051 0.5
Schistosoma mansoni hypothetical protein 0.0031 0.0066 0.0672
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0006 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0602
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0122 0.0071
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.4035 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0066 0.0602
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.4035 1 0.5
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0066 0.2499
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0017 0.0104
Echinococcus multilocularis GPCR, family 2 0.0031 0.0066 0.0602

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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