Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | pantothenate kinase, putative | 0.0076 | 0.3655 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0076 | 0.3655 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0077 | 0.3736 | 1 |
Onchocerca volvulus | 0.0077 | 0.3736 | 0.2889 | |
Loa Loa (eye worm) | pantothenate kinase | 0.0076 | 0.3655 | 0.3615 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Cation transporter family protein | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | nAChR subunit | 0.0046 | 0.1191 | 0.307 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0076 | 0.3655 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0077 | 0.3736 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0046 | 0.1191 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Onchocerca volvulus | 0.0152 | 1 | 1 | |
Loa Loa (eye worm) | GABA receptor subunit | 0.0046 | 0.1191 | 0.1135 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0152 | 1 | 1 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0077 | 0.3736 | 1 |
Onchocerca volvulus | 0.0077 | 0.3736 | 0.2889 | |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0077 | 0.3736 | 1 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0077 | 0.3736 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0077 | 0.3736 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0046 | 0.1191 | 0.1135 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | ACC-1 protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0046 | 0.1191 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.7455 | 0.7439 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0152 | 1 | 1 |
Brugia malayi | Cation transporter family protein | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0046 | 0.1191 | 0.1135 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0046 | 0.1191 | 0.1135 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0046 | 0.1191 | 0.1135 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0077 | 0.3736 | 0.3696 |
Giardia lamblia | Pantothenate kinase 4 | 0.0076 | 0.3655 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 1 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0077 | 0.3736 | 1 |
Echinococcus multilocularis | nAChR subunit | 0.0077 | 0.3736 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0077 | 0.3736 | 0.3696 |
Leishmania major | pantothenate kinase subunit, putative | 0.0076 | 0.3655 | 0.5 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Onchocerca volvulus | 0.0152 | 1 | 1 | |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0077 | 0.3736 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0076 | 0.3655 | 1 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Toxoplasma gondii | fumble protein | 0.0076 | 0.3655 | 1 |
Loa Loa (eye worm) | LGC-31 protein | 0.0077 | 0.3736 | 0.3696 |
Onchocerca volvulus | Fumble homolog | 0.0076 | 0.3655 | 0.2798 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0076 | 0.3655 | 0.5 |
Echinococcus granulosus | nAChR subunit | 0.0077 | 0.3736 | 1 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0077 | 0.3736 | 1 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | pantothenate kinase | 0.0076 | 0.3655 | 0.3615 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Onchocerca volvulus | Putative nachr subunit | 0.0077 | 0.3736 | 0.2889 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | pantothenate kinase family protein | 0.0076 | 0.3655 | 0.3615 |
Schistosoma mansoni | pantothenate kinase | 0.0076 | 0.3655 | 0.3615 |
Echinococcus multilocularis | nAChR subunit | 0.0046 | 0.1191 | 0.307 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0076 | 0.3655 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0077 | 0.3736 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0046 | 0.1191 | 0.1135 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0077 | 0.3736 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0077 | 0.3736 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0077 | 0.3736 | 0.3696 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0077 | 0.3736 | 0.3696 |
Onchocerca volvulus | 0.0077 | 0.3736 | 0.2889 | |
Echinococcus granulosus | pantothenate kinase 4 | 0.0076 | 0.3655 | 0.9781 |
Schistosoma mansoni | nAChR subunit | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.0076 | 0.3655 | 0.9781 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0077 | 0.3736 | 1 |
Onchocerca volvulus | 0.0152 | 1 | 1 | |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.0076 | 0.3655 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0077 | 0.3736 | 1 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0077 | 0.3736 | 1 |
Plasmodium falciparum | pantothenate kinase 1, putative | 0.0076 | 0.3655 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0077 | 0.3736 | 1 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0077 | 0.3736 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0982 | 0.2559 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.0076 | 0.3655 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.3736 | 0.3696 |
Plasmodium vivax | pantothenate kinase, putative | 0.0076 | 0.3655 | 1 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0077 | 0.3736 | 0.3696 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0077 | 0.3736 | 0.3696 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0077 | 0.3736 | 1 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0077 | 0.3736 | 0.3696 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1191 | 0.1135 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0076 | 0.3655 | 1 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0077 | 0.3736 | 0.3696 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.