Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0073 | 0.3593 | 0.3593 |
Plasmodium falciparum | pantothenate kinase 1, putative | 0.0085 | 0.4705 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0085 | 0.4705 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0085 | 0.4705 | 1 |
Toxoplasma gondii | fumble protein | 0.0085 | 0.4705 | 1 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0044 | 0.099 | 0.099 |
Brugia malayi | acetylcholine receptor alpha subunit precursor, putative | 0.0073 | 0.3593 | 0.3593 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0085 | 0.4705 | 1 |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1371 | 0.1371 |
Echinococcus granulosus | nAChR subunit | 0.0044 | 0.099 | 0.1992 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0049 | 0.1467 | 0.3019 |
Onchocerca volvulus | 0.0144 | 1 | 1 | |
Loa Loa (eye worm) | glutamate-gated chloride channel alpha3A subunit | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.7397 | 0.7397 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | pantothenate kinase 4 | 0.0085 | 0.4705 | 1 |
Plasmodium vivax | pantothenate kinase, putative | 0.0085 | 0.4705 | 1 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0073 | 0.3593 | 0.7603 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1371 | 0.1371 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | acetylcholine receptor, alpha-type subunit unc-38 precursor | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta-like) | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Onchocerca volvulus | 0.0144 | 1 | 1 | |
Loa Loa (eye worm) | LGC-31 protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0073 | 0.3593 | 0.3593 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0085 | 0.4705 | 0.5 |
Loa Loa (eye worm) | ACC-1 protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | nicotinic acetylcholine receptor beta-1 chain precursor | 0.0073 | 0.3593 | 0.3593 |
Echinococcus multilocularis | Cys loop ligand gated ion channel subunit | 0.0073 | 0.3593 | 0.7603 |
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0073 | 0.3593 | 0.3593 |
Echinococcus granulosus | nicotinic acetylcholine receptor alpha subunit | 0.0073 | 0.3593 | 0.7603 |
Brugia malayi | nicotinic acetylcholine receptor alpha subunit, putative | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | acetylcholine receptor protein, alpha-like chain, putative | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0044 | 0.099 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | excitatory GABA receptor EXP-1A | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1371 | 0.1371 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit type | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Schistosoma mansoni | nAChR subunit (ShAR1-alpha-like) | 0.0144 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Onchocerca volvulus | Putative nachr subunit | 0.0073 | 0.3593 | 0.2889 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor alpha subunit | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | glutamate-gated chloride channel alpha3A subunit, putative | 0.0044 | 0.099 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.0085 | 0.4705 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0085 | 0.4705 | 1 |
Echinococcus multilocularis | acetylcholine receptor subunit beta 1 | 0.0073 | 0.3593 | 0.7603 |
Onchocerca volvulus | 0.0073 | 0.3593 | 0.2889 | |
Schistosoma mansoni | rotamase | 0.0034 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | nicotinic acetylcholine receptor non-alpha subunit | 0.0073 | 0.3593 | 0.3593 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0085 | 0.4705 | 0.5 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0085 | 0.4705 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Onchocerca volvulus | 0.0144 | 1 | 1 | |
Echinococcus multilocularis | nicotinic acetylcholine receptor beta 1 subunit | 0.0073 | 0.3593 | 0.7603 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0034 | 0.0066 | 0.0066 |
Loa Loa (eye worm) | ligand-Gated ion Channel family member | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | excitatory GABA receptor EXP-1A | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Hypothetical glycine receptor like protein T20B12.9 in chromosome III | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Echinococcus granulosus | nicotinic acetylcholine receptor beta 1 subunit | 0.0073 | 0.3593 | 0.7603 |
Echinococcus multilocularis | nAChR subunit | 0.0073 | 0.3593 | 0.7603 |
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | hypothetical protein | 0.0144 | 1 | 1 |
Brugia malayi | pantothenate kinase family protein | 0.0085 | 0.4705 | 0.4705 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0073 | 0.3593 | 0.3593 |
Onchocerca volvulus | 0.0073 | 0.3593 | 0.2889 | |
Echinococcus multilocularis | glycine receptor subunit beta | 0.0073 | 0.3593 | 0.7603 |
Echinococcus multilocularis | neuronal acetylcholine receptor subunit alpha 4 | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Echinococcus granulosus | nAChR subunit | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0073 | 0.3593 | 0.7603 |
Echinococcus multilocularis | nicotinic acetylcholine receptor subunit alpha 8 | 0.0073 | 0.3593 | 0.7603 |
Onchocerca volvulus | Fumble homolog | 0.0085 | 0.4705 | 0.4123 |
Echinococcus granulosus | neuronal acetylcholine receptor subunit alpha 4 | 0.0073 | 0.3593 | 0.7603 |
Echinococcus multilocularis | nicotinic acetylcholine receptor a11 subunit | 0.0073 | 0.3593 | 0.7603 |
Echinococcus granulosus | nicotinic acetylcholine receptor subunit alpha 8 | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | GABA receptor subunit | 0.0044 | 0.099 | 0.099 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.0085 | 0.4705 | 1 |
Loa Loa (eye worm) | ACC-1 protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0073 | 0.3593 | 0.3593 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0034 | 0.0066 | 0.0066 |
Echinococcus multilocularis | nAChR subunit | 0.0044 | 0.099 | 0.1992 |
Schistosoma mansoni | neurotransmitter gated ion channel | 0.0044 | 0.099 | 0.099 |
Echinococcus multilocularis | glycine receptor subunit alpha 1 | 0.0073 | 0.3593 | 0.7603 |
Echinococcus granulosus | nicotinic acetylcholine receptor a11 subunit | 0.0073 | 0.3593 | 0.7603 |
Onchocerca volvulus | 0.0073 | 0.3593 | 0.2889 | |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | nicotinic acetylcholine receptor alpha | 0.0044 | 0.099 | 0.099 |
Brugia malayi | Cation transporter family protein | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | pantothenate kinase | 0.0085 | 0.4705 | 0.4705 |
Brugia malayi | Cation transporter family protein | 0.0073 | 0.3593 | 0.3593 |
Leishmania major | pantothenate kinase subunit, putative | 0.0085 | 0.4705 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Echinococcus granulosus | acetylcholine receptor subunit beta 1 | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | pantothenate kinase | 0.0085 | 0.4705 | 0.4705 |
Schistosoma mansoni | nAChR subunit (ShAR1-beta2-like) | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Schistosoma mansoni | nAChR subunit | 0.0073 | 0.3593 | 0.3593 |
Loa Loa (eye worm) | acetylcholine receptor alpha subunit | 0.0073 | 0.3593 | 0.3593 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0073 | 0.3593 | 0.3593 |
Giardia lamblia | Pantothenate kinase 4 | 0.0085 | 0.4705 | 0.5 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0044 | 0.099 | 0.099 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1371 | 0.1371 |
Brugia malayi | Neurotransmitter-gated ion-channel transmembrane region family protein | 0.0044 | 0.099 | 0.099 |
Loa Loa (eye worm) | pantothenate kinase | 0.0085 | 0.4705 | 0.4705 |
Echinococcus granulosus | glycine receptor subunit alpha 1 | 0.0073 | 0.3593 | 0.7603 |
Echinococcus granulosus | Cys loop ligand gated ion channel subunit | 0.0073 | 0.3593 | 0.7603 |
Schistosoma mansoni | Cys-loop ligand gated ion channel subunit | 0.0073 | 0.3593 | 0.3593 |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.0085 | 0.4705 | 0.5 |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | 0.0073 | 0.3593 | 0.3593 |
Echinococcus multilocularis | nicotinic acetylcholine receptor alpha subunit | 0.0073 | 0.3593 | 0.7603 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.099 | 0.099 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.3593 | 0.3593 |
Echinococcus granulosus | glycine receptor subunit beta | 0.0073 | 0.3593 | 0.7603 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.