Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0077 | 0.1544 | 0.5 |
Trypanosoma brucei | rieske iron-sulfur protein, mitochondrial precursor | 0.0077 | 0.1544 | 0.5 |
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0168 | 0.6348 | 0.6348 |
Trypanosoma cruzi | rieske iron-sulfur protein, mitochondrial precursor, putative | 0.0077 | 0.1544 | 0.5 |
Schistosoma mansoni | ubiquinol--cytochrome C reductase | 0.0168 | 0.6348 | 0.9857 |
Toxoplasma gondii | ubiquinol cytochrome c oxidoreductase, putative | 0.0077 | 0.1544 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.644 | 1 |
Echinococcus granulosus | geminin | 0.0169 | 0.644 | 0.0252 |
Loa Loa (eye worm) | hypothetical protein | 0.0237 | 1 | 1 |
Brugia malayi | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein | 0.0168 | 0.6348 | 0.6348 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0237 | 1 | 1 |
Plasmodium vivax | ubiquinol cytochrome c oxidoreductase, putative | 0.0077 | 0.1544 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0237 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | Rieske Fe-S protein | 0.0077 | 0.1544 | 0.5 |
Plasmodium falciparum | cytochrome b-c1 complex subunit Rieske, putative | 0.0077 | 0.1544 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.644 | 1 |
Echinococcus multilocularis | geminin | 0.0169 | 0.644 | 0.0252 |
Leishmania major | reiske iron-sulfur protein precursor, putative | 0.0077 | 0.1544 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.