pI: 9.0466 |
Length (AA): 243 |
MW (Da): 27466 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 1
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 3 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
47 | 241 | 2a06 (E) | 1 | 196 | 47.00 | 0 | 1 | 1.19257 | 0.52 |
47 | 241 | 1bcc (E) | 1 | 196 | 45.00 | 0 | 1 | 1.25657 | 0.68 |
183 | 225 | 1g8k (B) | 59 | 102 | 35.00 | 0.26 | 1 | 0.678055 | -1.29 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_127574)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT5G13430 | ubiquinol-cytochrome C reductase iron-sulfur subunit |
Arabidopsis thaliana | AT5G13440 | ubiquinol-cytochrome C reductase iron-sulfur subunit |
Babesia bovis | BBOV_III009930 | ubiquinol cytochrome c oxidoreductase, putative |
Brugia malayi | Bm1_46150 | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein |
Brugia malayi | Bm1_46185 | ubiquinol-cytochrome c reductase, iron-sulfur subunit family protein |
Candida albicans | CaO19.13314 | similar to S. cerevisiae RIP1 (YEL024W) mitochondrial cytochrome bc1 complex Rieske iron-sulfur protein |
Candida albicans | CaO19.5893 | similar to S. cerevisiae RIP1 (YEL024W) mitochondrial cytochrome bc1 complex Rieske iron-sulfur protein |
Caenorhabditis elegans | CELE_F42G8.12 | Protein ISP-1 |
Dictyostelium discoideum | DDB_G0284947 | Rieske iron-sulfur protein |
Drosophila melanogaster | Dmel_CG7361 | Rieske iron-sulfur protein |
Echinococcus granulosus | EgrG_000421550 | ubiquinol cytochrome c reductase Rieske |
Echinococcus multilocularis | EmuJ_000421550 | ubiquinol cytochrome c reductase, Rieske |
Homo sapiens | 7386 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
Leishmania braziliensis | LbrM.34.1450 | reiske iron-sulfur protein precursor, putative |
Leishmania donovani | LdBPK_351540.1 | rieske iron-sulfur protein, mitochondrial precursor, putative |
Leishmania infantum | LinJ.35.1540 | reiske iron-sulfur protein precursor, putative |
Leishmania major | LmjF.35.1540 | reiske iron-sulfur protein precursor, putative |
Leishmania mexicana | LmxM.34.1540 | reiske iron-sulfur protein precursor, putative |
Loa Loa (eye worm) | LOAG_09948 | ubiquinol-cytochrome c reductase |
Loa Loa (eye worm) | LOAG_08023 | hypothetical protein |
Mus musculus | ENSMUSG00000038462 | ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 |
Neospora caninum | NCLIV_010020 | Ubiquinol-cytochrome c reductase iron-sulfur subunit (EC 1.10.2.2), related |
Oryza sativa | 4329497 | Os02g0520800 |
Oryza sativa | 4335710 | Os04g0398500 |
Plasmodium berghei | PBANKA_1303300 | cytochrome b-c1 complex subunit Rieske, putative |
Plasmodium falciparum | PF3D7_1439400 | cytochrome b-c1 complex subunit Rieske, putative |
Plasmodium knowlesi | PKNH_1242900 | cytochrome b-c1 complex subunit Rieske, putative |
Plasmodium vivax | PVX_118520 | ubiquinol cytochrome c oxidoreductase, putative |
Plasmodium yoelii | PY05634 | ubiquinol-cytochrome c reductase, iron-sulfur subunit, putative |
Saccharomyces cerevisiae | YEL024W | ubiquinol--cytochrome-c reductase catalytic subunit RIP1 |
Schistosoma japonicum | Sjp_0217930 | ko:K00411 ubiquinol-cytochrome c reductase iron-sulfur subunit, putative |
Schistosoma mansoni | Smp_061870 | ubiquinol--cytochrome C reductase |
Schmidtea mediterranea | mk4.000449.05 | Cytochrome b-c1 complex subunit Rieske, mitochondrial |
Trypanosoma brucei gambiense | Tbg972.9.8870 | reiske iron-sulfur protein, mitochondrial precursor |
Trypanosoma brucei | Tb927.9.14160 | rieske iron-sulfur protein, mitochondrial precursor |
Trypanosoma congolense | TcIL3000_9_6080 | rieske iron-sulfur protein, mitochondrial precursor |
Trypanosoma cruzi | TcCLB.510759.120 | rieske iron-sulfur protein, mitochondrial precursor, putative |
Trypanosoma cruzi | TcCLB.506999.90 | rieske iron-sulfur protein, mitochondrial precursor, putative |
Toxoplasma gondii | TGME49_320220 | ubiquinol cytochrome c oxidoreductase, putative |
Theileria parva | TP04_0913 | ubiquinol-cytochrome C reductase, iron-sulfur subunit, putative |
Wolbachia endosymbiont of Brugia malayi | Wbm0406 | Rieske Fe-S protein |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb09.211.4700 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (3 days) | alsford |
Tb09.211.4700 | Trypanosoma brucei | no significant loss or gain of fitness in bloodstream forms (6 days) | alsford |
Tb09.211.4700 | Trypanosoma brucei | no significant loss or gain of fitness in procyclic forms | alsford |
Tb09.211.4700 | Trypanosoma brucei | significant gain of fitness in differentiation of procyclic to bloodstream forms | alsford |
CELE_F42G8.12 | Caenorhabditis elegans | embryonic lethal | wormbase |
TGME49_320220 | Toxoplasma gondii | Probably essential | sidik |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Botryotinia fuckeliana (strain T4) (Noble rot fungus) (Botrytiscinerea) | Cytochrome b-c1 complex subunit Rieske, mitochondrial | Compounds | References |
Plasmodium falciparum | cytochrome b-c1 complex subunit Rieske, putative | Compounds | References |