Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0065 | 0.4786 | 0.4786 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.2209 | 0.2714 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0866 | 0.0866 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0037 | 0.207 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.5179 | 0.5434 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.5179 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0037 | 0.207 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.5179 | 0.5434 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0038 | 0.2209 | 0.2714 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7791 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0069 | 0.5179 | 0.4721 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0037 | 0.207 | 0.1317 |
Brugia malayi | chromobox protein homolog 3 | 0.0038 | 0.2209 | 0.2209 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0037 | 0.207 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7791 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.2209 | 0.147 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.207 | 1 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0038 | 0.2209 | 0.241 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.5179 | 0.5434 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0037 | 0.207 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.7791 | 1 |
Schistosoma mansoni | chromobox protein | 0.0069 | 0.5179 | 0.5434 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0037 | 0.207 | 0.5 |
Echinococcus granulosus | jun protein | 0.0082 | 0.6526 | 0.779 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0095 | 0.7791 | 0.7582 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0082 | 0.6526 | 0.779 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1391 | 0.0575 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0037 | 0.207 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.5008 | 0.5136 |
Brugia malayi | bZIP transcription factor family protein | 0.0082 | 0.6526 | 0.6526 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.7791 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0095 | 0.7791 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0037 | 0.207 | 0.207 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0095 | 0.7791 | 0.7791 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0082 | 0.6526 | 0.779 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0041 | 0.2497 | 0.3257 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.207 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.2497 | 0.3419 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0037 | 0.207 | 1 |
Brugia malayi | Heterochromatin protein 1 | 0.0069 | 0.5179 | 0.5179 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0095 | 0.7791 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0037 | 0.207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.6304 | 0.5954 |
Trichomonas vaginalis | chromobox protein, putative | 0.0041 | 0.2497 | 0.3419 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.207 | 0.2371 |
Echinococcus multilocularis | jun protein | 0.0082 | 0.6526 | 0.779 |
Echinococcus multilocularis | chromobox protein 1 | 0.0069 | 0.5179 | 0.5434 |
Schistosoma mansoni | jun-related protein | 0.0067 | 0.5008 | 0.5136 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0095 | 0.7791 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.0037 | 0.207 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0037 | 0.207 | 0.2371 |
Trichomonas vaginalis | chromobox protein, putative | 0.0069 | 0.5179 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0037 | 0.207 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0069 | 0.5179 | 0.5434 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0037 | 0.207 | 0.5 |
Onchocerca volvulus | 0.0065 | 0.4786 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.