Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.0011 | 0.017 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2826 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 18 protein | 0.0011 | 0.017 | 0.0193 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.017 | 0.0193 |
Echinococcus granulosus | Hepatocellular carcinoma associated antigen 59 | 0.0118 | 0.2826 | 0.2772 |
Onchocerca volvulus | Putative endochitinase | 0.0074 | 0.1743 | 0.5995 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.0009 | 0.0121 | 0.0011 |
Echinococcus multilocularis | Glycoside hydrolase, chitinase domain containing protein 1 | 0.0011 | 0.017 | 0.0096 |
Schistosoma mansoni | chitinase | 0.0011 | 0.017 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Trichomonas vaginalis | chitinase, putative | 0.0011 | 0.017 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0408 | 1 | 1 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0009 | 0.0121 | 0.0021 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.1809 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Echinococcus multilocularis | dnaJ subfamily B | 0.0408 | 1 | 1 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.1965 | 0.6817 |
Onchocerca volvulus | Putative chitinase | 0.0011 | 0.017 | 0.0182 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.017 | 0.0193 |
Echinococcus granulosus | Glycoside hydrolase chitinase domain containing protein 1 | 0.0011 | 0.017 | 0.0096 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.1471 | 0.4996 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0648 | 0.0648 |
Onchocerca volvulus | Putative endochitinase | 0.0011 | 0.017 | 0.0182 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.1403 | 0.1403 |
Onchocerca volvulus | Putative endochitinase | 0.0074 | 0.1743 | 0.5995 |
Loa Loa (eye worm) | chitinase I | 0.0074 | 0.1743 | 0.5999 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.0648 | 0.0578 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.1471 | 1 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.0648 | 0.0578 |
Brugia malayi | Hepatocellular carcinoma-associated antigen 59 family protein | 0.0118 | 0.2826 | 1 |
Brugia malayi | endochitinase | 0.0074 | 0.1743 | 0.6003 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Brugia malayi | endochitinase | 0.0083 | 0.1965 | 0.6823 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1529 | 0.5209 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1529 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0038 | 0.0842 | 0.0773 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0066 | 0.1529 | 0.8639 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0038 | 0.0842 | 0.0773 |
Loa Loa (eye worm) | hypothetical protein | 0.0118 | 0.2826 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1529 | 0.1465 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0118 | 0.0044 |
Loa Loa (eye worm) | chitin binding Peritrophin-A domain-containing protein | 0.0009 | 0.0121 | 0.0011 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0066 | 0.1529 | 0.5214 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0066 | 0.1529 | 0.1529 |
Entamoeba histolytica | chitinase, putative | 0.0074 | 0.1743 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.0648 | 0.0648 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.1965 | 0.6817 |
Brugia malayi | Endochitinase | 0.0011 | 0.017 | 0.0203 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0074 | 0.0074 |
Onchocerca volvulus | Putative endochitinase | 0.0083 | 0.1965 | 0.6817 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.2826 | 0.2826 |
Plasmodium vivax | hypothetical protein, conserved | 0.0118 | 0.2826 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0011 | 0.017 | 0.0203 |
Onchocerca volvulus | 0.0118 | 0.2826 | 1 | |
Onchocerca volvulus | 0.0118 | 0.2826 | 1 | |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.0608 | 0.1817 |
Loa Loa (eye worm) | cuticular endochitinase | 0.0074 | 0.1743 | 0.5999 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0009 | 0.0121 | 0.0021 |
Echinococcus multilocularis | Hepatocellular carcinoma associated antigen 59 | 0.0118 | 0.2826 | 0.2772 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Brugia malayi | hypothetical protein | 0.0011 | 0.017 | 0.0203 |
Leishmania major | chitinase | 0.0074 | 0.1743 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0118 | 0.2826 | 1 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0009 | 0.0121 | 0.0021 |
Plasmodium falciparum | conserved protein, unknown function | 0.0118 | 0.2826 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1529 | 0.5 |
Mycobacterium ulcerans | chitinase/cellulase | 0.0064 | 0.1471 | 1 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0066 | 0.1529 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0121 | 0.0011 |
Onchocerca volvulus | 0.0029 | 0.0608 | 0.18 | |
Mycobacterium tuberculosis | Possible chitinase | 0.0064 | 0.1471 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 18 protein | 0.0011 | 0.017 | 0.0203 |
Brugia malayi | Endochitinase | 0.0083 | 0.1965 | 0.6823 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.0608 | 0.0608 |
Loa Loa (eye worm) | microfilarial chitinase | 0.0073 | 0.1693 | 0.5817 |
Brugia malayi | Chitin binding Peritrophin-A domain containing protein | 0.0009 | 0.0121 | 0.0021 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0066 | 0.1529 | 0.1465 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.