Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | carbonic anhydrase | 0.0227 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0149 | 0.5458 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0067 | 0.0707 | 1 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0067 | 0.0707 | 0.1296 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0227 | 1 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0067 | 0.0707 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0067 | 0.0707 | 0.5 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0067 | 0.0707 | 0.1296 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0149 | 0.5458 | 0.5458 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0129 | 0.4282 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0149 | 0.5458 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0067 | 0.0707 | 0.1296 |
Toxoplasma gondii | thioredoxin reductase | 0.0067 | 0.0707 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0149 | 0.5458 | 1 |
Brugia malayi | glutathione reductase | 0.0067 | 0.0707 | 0.1296 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0149 | 0.5458 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0098 | 0.2495 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0149 | 0.5458 | 0.5458 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0149 | 0.5458 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0067 | 0.0707 | 0.1296 |
Leishmania major | carbonic anhydrase-like protein | 0.0149 | 0.5458 | 0.5113 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0149 | 0.5458 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0149 | 0.5458 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0098 | 0.2495 | 0.5 |
Loa Loa (eye worm) | glutathione reductase | 0.0067 | 0.0707 | 0.1296 |
Schistosoma mansoni | carbonic anhydrase | 0.0227 | 1 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0098 | 0.2495 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0149 | 0.5458 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0149 | 0.5458 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0227 | 1 | 0.5 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0067 | 0.0707 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.