Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0596 | 0.0804 |
Brugia malayi | follicle stimulating hormone receptor | 0.0242 | 0.6974 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0596 | 0.0804 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.015 | 0.2513 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.3754 | 0.3754 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0049 | 0.0885 | 0.0885 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0596 | 0.1478 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0596 | 0.0804 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.015 | 0.2513 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 1 | 1 |
Brugia malayi | beta-lactamase | 0.004 | 0.0596 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.0654 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.3754 | 0.3754 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0885 | 0.1078 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0596 | 0.1478 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0596 | 0.0804 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0596 | 0.0654 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0596 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.1637 | 0.2348 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.1637 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.014 | 0.3754 | 0.5281 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.0654 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0596 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.1637 | 0.5 |
Brugia malayi | hypothetical protein | 0.0026 | 0.015 | 0.0215 |
Wolbachia endosymbiont of Brugia malayi | acetylornithine transaminase protein | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.3754 | 0.3754 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.015 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.1637 | 0.1637 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.0654 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0596 | 0.0804 |
Mycobacterium tuberculosis | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA | 0.0149 | 0.4032 | 0.5442 |
Mycobacterium tuberculosis | Probable aminotransferase | 0.0149 | 0.4032 | 0.5442 |
Onchocerca volvulus | 0.0049 | 0.0885 | 1 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.014 | 0.3754 | 0.5382 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0596 | 0.0804 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.1637 | 0.1637 |
Trichomonas vaginalis | acetylornithine aminotransferase, putative | 0.0149 | 0.4032 | 1 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0596 | 0.0804 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0596 | 0.1478 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0596 | 0.1478 |
Brugia malayi | Cytochrome P450 family protein | 0.0048 | 0.0852 | 0.1221 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0596 | 0.1478 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.014 | 0.3754 | 0.3754 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0596 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0596 | 0.1478 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.0654 |
Mycobacterium leprae | PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA | 0.0149 | 0.4032 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.0654 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.1637 | 0.1637 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.015 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0149 | 0.4032 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0596 | 0.0804 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.3754 | 0.3754 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0256 | 0.7409 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.014 | 0.3754 | 0.3754 |
Echinococcus multilocularis | tumor protein p63 | 0.0336 | 0.9946 | 0.9946 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0596 | 0.0804 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.1637 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.1637 | 0.1637 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0596 | 0.1478 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0048 | 0.0852 | 0.1029 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0596 | 0.0855 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.014 | 0.3754 | 0.3754 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0596 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0338 | 1 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0596 | 0.0596 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0596 | 0.0596 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0596 | 0.0654 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0596 | 0.0654 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0596 | 0.0804 |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0596 | 1 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0596 | 0.0855 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0242 | 0.6974 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0596 | 0.0596 |
Echinococcus granulosus | tumor protein p63 | 0.0336 | 0.9946 | 0.9946 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.1637 | 0.5 |
Echinococcus multilocularis | geminin | 0.0338 | 1 | 1 |
Chlamydia trachomatis | glutamate-1-semialdehyde-2,1-aminomutase | 0.0021 | 0 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0596 | 0.0855 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0596 | 0.0596 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0596 | 1 |
Mycobacterium ulcerans | adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 0.0149 | 0.4032 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.