Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0198 | 0.2909 | 0.5 |
Echinococcus multilocularis | muscleblind protein | 0.0147 | 0.1625 | 0.1625 |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0198 | 0.2909 | 0.5 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0324 | 0.6021 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0324 | 0.6021 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0339 | 0.6387 | 0.6387 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0198 | 0.2909 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0324 | 0.6021 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0198 | 0.2909 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0324 | 0.6021 | 0.5 |
Echinococcus granulosus | muscleblind protein | 0.0147 | 0.1625 | 0.1625 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0198 | 0.2909 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0484 | 1 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0198 | 0.2909 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0324 | 0.6021 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.0147 | 0.1625 | 0.2699 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0147 | 0.1625 | 0.1625 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1625 | 0.2699 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0484 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0198 | 0.2909 | 1 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0198 | 0.2909 | 0.5 |
Onchocerca volvulus | 0.0081 | 0 | 0.5 | |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0198 | 0.2909 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.1625 | 0.2699 |
Loa Loa (eye worm) | hypothetical protein | 0.0166 | 0.2096 | 0.3481 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.