Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tm gpcr rhodopsin | 0.1118 | 0.7338 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1456 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1456 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1456 | 1 | 1 |
Echinococcus granulosus | hypothetical protein | 0.066 | 0.3734 | 0.5089 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0525 | 0.2671 | 0.3639 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0525 | 0.2671 | 0.5 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1118 | 0.7338 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0525 | 0.2671 | 0.3639 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0603 | 0.3287 | 0.4479 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0525 | 0.2671 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0525 | 0.2671 | 0.0663 |
Loa Loa (eye worm) | hypothetical protein | 0.055 | 0.2869 | 0.027 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1456 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.