Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | conserved hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Echinococcus granulosus | hypothetical protein | Get druggable targets OG5_144688 | All targets in OG5_144688 |
Brugia malayi | Serotonin receptor | Get druggable targets OG5_135430 | All targets in OG5_135430 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0693 | 0.0688 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2535 | 0.387 |
Onchocerca volvulus | 0.0264 | 0.2535 | 0.4231 | |
Echinococcus granulosus | sodium channel protein | 0.0083 | 0.0592 | 0.0587 |
Brugia malayi | Matrixin family protein | 0.0264 | 0.2535 | 0.3865 |
Echinococcus multilocularis | conserved hypothetical protein | 0.0833 | 0.8629 | 0.8628 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0693 | 0.0688 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.0693 | 0.1051 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2535 | 0.387 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1628 | 0.437 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.0693 | 0.0688 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0961 | 1 | 1 |
Echinococcus multilocularis | sodium channel protein | 0.0083 | 0.0592 | 0.0587 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2535 | 0.387 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0693 | 0.1852 |
Schistosoma mansoni | hypothetical protein | 0.0375 | 0.3719 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0006 | 0.0008 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0264 | 0.2535 | 0.387 |
Brugia malayi | Matrixin family protein | 0.0639 | 0.6551 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0693 | 0.1852 |
Echinococcus granulosus | voltage gated sodium channel Nav1 alpha subunit | 0.0083 | 0.0592 | 0.0587 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0264 | 0.2535 | 0.6813 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.0693 | 0.1852 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0322 | 0.3152 | 0.5 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0322 | 0.3152 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0564 | 0.5746 | 0.877 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0322 | 0.3152 | 0.4808 |
Loa Loa (eye worm) | matrixin family protein | 0.0639 | 0.6551 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0586 | 0.5984 | 0.9136 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0586 | 0.5984 | 1 |
Echinococcus granulosus | hypothetical protein | 0.0842 | 0.8721 | 0.872 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.0693 | 0.1058 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0006 | 0.0008 |
Brugia malayi | Hemopexin family protein | 0.0375 | 0.3719 | 0.5673 |
Echinococcus granulosus | geminin | 0.018 | 0.1628 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.3152 | 0.4812 |
Brugia malayi | Matrixin family protein | 0.0264 | 0.2535 | 0.3865 |
Onchocerca volvulus | Matrilysin homolog | 0.0264 | 0.2535 | 0.4231 |
Onchocerca volvulus | Matrilysin homolog | 0.0586 | 0.5984 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0322 | 0.3152 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.018 | 0.1628 | 0.437 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.031 | 0.3018 | 0.8113 |
Brugia malayi | Matrixin family protein | 0.0264 | 0.2535 | 0.3865 |
Onchocerca volvulus | 0.0375 | 0.3719 | 0.6211 | |
Leishmania major | calcium channel protein, putative,ion transporter, putative | 0.0083 | 0.0592 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0006 | 0.0008 |
Echinococcus multilocularis | geminin | 0.018 | 0.1628 | 0.1624 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.0693 | 0.0688 |
Brugia malayi | Matrixin family protein | 0.0264 | 0.2535 | 0.3865 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = -8.3 | In vitro binding affinity at human cloned 5-hydroxytryptamine 2C receptor of HEK293 cells by [3H]-mesulergine displacement. | ChEMBL. | 10969987 |
Ki (binding) | = -7.1 | In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]-5-HT displacement. | ChEMBL. | 10969987 |
Ki (binding) | = -6.6 | In vitro binding affinity at human cloned 5-hydroxytryptamine 2A receptor of HEK293 cells by [3H]-ketanserin displacement. | ChEMBL. | 10969987 |
Log Ki (binding) | = 6.6 | In vitro binding affinity at human cloned 5-hydroxytryptamine 2A receptor of HEK293 cells by [3H]-ketanserin displacement. | ChEMBL. | 10969987 |
Log Ki (binding) | = 7.1 | In vitro binding affinity at human cloned 5-hydroxytryptamine 2B receptor of HEK293 cells by [3H]-5-HT displacement. | ChEMBL. | 10969987 |
Log Ki (binding) | = 8.3 | In vitro binding affinity at human cloned 5-hydroxytryptamine 2C receptor of HEK293 cells by [3H]-mesulergine displacement. | ChEMBL. | 10969987 |
Selectivity (binding) | = 15 | Selectivity at serotonin 5-HT 2C receptor compared to serotonin 5-HT 2B receptor | ChEMBL. | 10969987 |
Selectivity (binding) | = 50 | Selectivity at 5-HT 2C receptor compared to serotonin 5-HT 2A receptor | ChEMBL. | 10969987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.