Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0234 | 0.5806 | 1 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0234 | 0.5806 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 1 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0234 | 0.5806 | 0.5806 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0234 | 0.5806 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.039 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.039 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0234 | 0.5806 | 0.5806 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0234 | 0.5806 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0199 | 0.4869 | 0.4869 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.039 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.