Detailed information for compound 795109

Basic information

Technical information
  • TDR Targets ID: 795109
  • Name: N-butyl-5-cyclopropyl-1,2-oxazole-3-carboxami de
  • MW: 208.257 | Formula: C11H16N2O2
  • H donors: 1 H acceptors: 2 LogP: 1.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)c1noc(c1)C1CC1
  • InChi: 1S/C11H16N2O2/c1-2-3-6-12-11(14)9-7-10(15-13-9)8-4-5-8/h7-8H,2-6H2,1H3,(H,12,14)
  • InChiKey: YSEQICONOROROH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-butyl-5-cyclopropyl-isoxazole-3-carboxamide
  • N-butyl-5-cyclopropyl-3-isoxazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0036 0.7702 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.1198 0.1198
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.1198 0.1198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 1 1
Schistosoma mansoni hypothetical protein 0.0036 0.7702 0.7702
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.1198 0.1198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.1198 0.1198
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 1 1
Entamoeba histolytica hypothetical protein 0.0036 0.7702 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.1198 0.1198
Brugia malayi nuclear hormone receptor 0.001 0.1198 0.1198
Onchocerca volvulus Bile acid receptor homolog 0.001 0.1198 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.1198 0.1198
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.7702 0.7702
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.1198 0.1198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.1198 0.1198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.7702 0.7702
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.1198 0.1198
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.1198 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.1198 0.1198
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.1198 0.1198
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.1198 0.1198
Echinococcus multilocularis FTZ F1 alpha 0.001 0.1198 0.1198
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.1198 0.1198
Brugia malayi hypothetical protein 0.0036 0.7702 0.7702
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.1198 0.1198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Brugia malayi steroid hormone receptor 0.001 0.1198 0.1198
Echinococcus granulosus FTZ F1 alpha 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.1198 0.1198
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.1198 0.1198
Schistosoma mansoni nuclear hormone receptor 0.001 0.1198 0.1198
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.1198 0.1198
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.1198 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.1198 0.1198
Brugia malayi Steroid receptor seven-up type 2 0.001 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.1198 0.1198
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.1198 0.1198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 1 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.1198 0.1198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.1198 0.1198
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.1198 0.1198
Entamoeba histolytica hypothetical protein 0.0036 0.7702 0.5
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.1198 0.1198
Brugia malayi ecdysteroid receptor 0.001 0.1198 0.1198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.1198 0.1198
Schistosoma mansoni thyroid hormone receptor 0.001 0.1198 0.1198
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.1198 0.1198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.1198 0.1198
Entamoeba histolytica hypothetical protein 0.0036 0.7702 0.5
Schistosoma mansoni coup transcription factor 0.001 0.1198 0.1198
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.1198 0.1198
Schistosoma mansoni thyroid hormone receptor 0.001 0.1198 0.1198
Brugia malayi nuclear receptor NHR-88 0.001 0.1198 0.1198
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 1 1
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Onchocerca volvulus 0.001 0.1198 0.5
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.1198 0.1198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.1198 0.1198
Loa Loa (eye worm) hypothetical protein 0.001 0.1198 0.1198
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.1198 0.1198
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.1198 0.1198
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.7702 0.7702
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.1198 0.1198
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.1198 0.1198
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.1198 0.1198
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.1198 0.1198
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.1198 0.1198
Loa Loa (eye worm) steroid hormone receptor 0.001 0.1198 0.1198

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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