Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0179 | 0.046 | 1 |
Echinococcus multilocularis | geminin | 0.0174 | 0.0439 | 0.0362 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.0308 | 0.0229 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0136 | 0.0308 | 0.0308 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0296 | 0.0872 | 0.2132 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.0322 | 0.3049 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0081 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0072 | 0.0081 | 0.0081 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0081 | 0.0081 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0179 | 0.046 | 0.4791 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0439 | 0.0362 |
Brugia malayi | beta-lactamase | 0.0072 | 0.0081 | 0.0081 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0296 | 0.0872 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0072 | 0.0081 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.0378 | 0.7837 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0179 | 0.046 | 0.2781 |
Brugia malayi | beta-lactamase family protein | 0.0072 | 0.0081 | 0.0081 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0179 | 0.046 | 0.0382 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.0308 | 0.0229 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0072 | 0.0081 | 0.0081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.0308 | 0.0229 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2887 | 1 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0072 | 0.0081 | 0.5 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1125 | 0.3791 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0081 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0072 | 0.0081 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0081 | 0.0081 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0179 | 0.046 | 0.0382 |
Onchocerca volvulus | 0.0072 | 0.0081 | 0.5 | |
Mycobacterium leprae | Probable lipase LipE | 0.0072 | 0.0081 | 0.5 |
Echinococcus granulosus | geminin | 0.0174 | 0.0439 | 0.0362 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.1125 | 0.3791 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0179 | 0.046 | 1 |
Onchocerca volvulus | 0.0072 | 0.0081 | 0.5 | |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0081 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0081 | 0.0195 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0136 | 0.0308 | 0.0229 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0072 | 0.0081 | 0.0195 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.0308 | 0.0229 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0179 | 0.046 | 0.0382 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0179 | 0.046 | 0.0382 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0156 | 0.0378 | 0.218 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.0872 | 0.2286 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0081 | 0.0081 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0136 | 0.0308 | 0.0229 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0081 | 0.5 |
Trypanosoma brucei | Aph-1 protein, putative | 0.1125 | 0.3791 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0136 | 0.0308 | 0.0308 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0081 | 0.0081 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2887 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0136 | 0.0308 | 0.0229 |
Schistosoma mansoni | hypothetical protein | 0.0174 | 0.0439 | 0.0362 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.014 | 0.0322 | 0.0833 |
Loa Loa (eye worm) | beta-lactamase | 0.0072 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0081 | 0.0081 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2887 | 1 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0459 | 0.1443 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0072 | 0.0081 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2887 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.014 | 0.0322 | 0.065 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0179 | 0.046 | 1 |
Onchocerca volvulus | 0.0072 | 0.0081 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0296 | 0.0872 | 0.2286 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0179 | 0.046 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.