Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0098 | 0.0098 |
Loa Loa (eye worm) | hypothetical protein | 0.064 | 0.3092 | 0.3092 |
Echinococcus granulosus | serotonin transporter | 0.0173 | 0.0681 | 0.0612 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0098 | 0.0098 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0173 | 0.0681 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0681 | 0.0681 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1253 | 0.6253 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0073 | 0.0073 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0073 | 0.0073 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | serotonin transporter b | 0.0173 | 0.0681 | 0.0681 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1253 | 0.6253 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0173 | 0.0681 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.1253 | 0.6253 | 0.6253 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1979 | 1 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1979 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0073 | 0.0073 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0681 | 0.0681 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0098 | 0.0098 |
Echinococcus multilocularis | serotonin transporter | 0.0173 | 0.0681 | 0.0612 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0173 | 0.0681 | 0.0681 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.1253 | 0.6253 | 0.6253 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0073 | 0.0073 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0173 | 0.0681 | 0.0681 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1979 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0173 | 0.0681 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0098 | 0.0098 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1979 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0173 | 0.0681 | 0.0681 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1979 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0173 | 0.0681 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1253 | 0.6253 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.