Detailed information for compound 798204

Basic information

Technical information
  • TDR Targets ID: 798204
  • Name: 2-[[4,5-di(phenyl)-1H-imidazol-2-yl]sulfanyl] propanoic acid
  • MW: 324.397 | Formula: C18H16N2O2S
  • H donors: 2 H acceptors: 3 LogP: 4.05 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(Sc1nc(c([nH]1)c1ccccc1)c1ccccc1)C
  • InChi: 1S/C18H16N2O2S/c1-12(17(21)22)23-18-19-15(13-8-4-2-5-9-13)16(20-18)14-10-6-3-7-11-14/h2-12H,1H3,(H,19,20)(H,21,22)
  • InChiKey: MFJVYXLNZAGCGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4,5-di(phenyl)-1H-imidazol-2-yl]thio]propanoic acid
  • 2-[[4,5-di(phenyl)-1H-imidazol-2-yl]thio]propionic acid
  • AF-872/33879022
  • A2769/0117355
  • IDI1_015904
  • Oprea1_843517
  • Maybridge3_004517
  • SR-01000537952-2

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0044 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus muscleblind protein 0.0156 0.0443 0.0627
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Echinococcus granulosus neuropeptide Y receptor 0.0105 0.0265 0.0375
Echinococcus granulosus g protein coupled receptor 0.0105 0.0265 0.0375
Schistosoma mansoni amine GPCR 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi AKH receptor 0.0105 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0164 0.0471 0.0667
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0105 0.0265 0.0375
Brugia malayi G-protein coupled receptor 0.0105 0.0265 0.0265
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.0281 0.0398
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0105 0.0265 0.0375
Echinococcus multilocularis vesicular acetylcholine transporter 0.2039 0.7061 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0105 0.0265 0.0375
Brugia malayi G-protein coupled receptor 0.0105 0.0265 0.0265
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis orexin receptor type 2 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis neuropeptides capa receptor 0.0105 0.0265 0.0375
Brugia malayi sulfakinin receptor protein 0.0105 0.0265 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis neuropeptide receptor 0.0105 0.0265 0.0375
Echinococcus granulosus neuropeptides capa receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0221 0.0221
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0105 0.0265 0.0375
Schistosoma mansoni hypothetical protein 0.0105 0.0265 0.0375
Echinococcus granulosus g-protein coupled receptor 0.0105 0.0265 0.0375
Schistosoma mansoni patched 1 0.0044 0.0049 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0105 0.0265 0.0375
Schistosoma mansoni biogenic amine receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis protein dispatched 1 0.005 0.0071 0.0101
Schistosoma mansoni hypothetical protein 0.0043 0.0044 0.0062
Echinococcus multilocularis g-protein coupled receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus biogenic amine 5HT receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0156 0.0443 0.0443
Loa Loa (eye worm) G-protein coupled receptor 0.0105 0.0265 0.0265
Echinococcus granulosus neuropeptides capa receptor 0.0105 0.0265 0.0375
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.0281 0.0281
Schistosoma mansoni neuropeptide receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Leishmania major C-8 sterol isomerase-like protein 0.2875 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis sterol regulatory element binding protein 0.0044 0.0049 0.007
Brugia malayi GnHR receptor homolog 0.0105 0.0265 0.0265
Echinococcus granulosus peptide allatostatin:somatostatin 0.0105 0.0265 0.0375
Echinococcus multilocularis sex peptide receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis g protein coupled receptor 0.0105 0.0265 0.0375
Schistosoma mansoni hypothetical protein 0.011 0.0281 0.0398
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0105 0.0265 0.0265
Echinococcus granulosus tachykinin peptides receptor 99D 0.0393 0.1275 0.1805
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Brugia malayi larval opioid receptor 0.0105 0.0265 0.0265
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0105 0.0265 0.0265
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0105 0.0265 0.0375
Echinococcus granulosus alpha 1A adrenergic receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi Melatonin receptor type 1A 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni biogenic amine receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis neuropeptide s receptor 0.0105 0.0265 0.0375
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0348 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni vesicular acetylcholine transporter 0.2039 0.7061 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0105 0.0265 0.0375
Echinococcus granulosus 7tm_1 domain containing protein 0.0105 0.0265 0.0375
Brugia malayi Muscleblind-like protein 0.0156 0.0443 0.0443
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis neuropeptide Y receptor 0.0105 0.0265 0.0375
Brugia malayi neuropeptide F receptor 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Schistosoma mansoni hypothetical protein 0.0322 0.1024 0.1451
Loa Loa (eye worm) neuropeptide F receptor 0.0105 0.0265 0.0265
Echinococcus granulosus tm gpcr rhodopsin 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0103 0.0256 0.0256
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0105 0.0265 0.0375
Brugia malayi Niemann-Pick C1 protein precursor 0.0103 0.0256 0.0256
Echinococcus multilocularis expressed conserved protein 0.0097 0.0234 0.0331
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0105 0.0265 0.0265
Echinococcus multilocularis fmrfamide receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0104 0.0261 0.037
Echinococcus multilocularis Niemann Pick C1 protein 0.0147 0.0411 0.0582
Schistosoma mansoni hypothetical protein 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.147 0.5059 0.5059
Schistosoma mansoni amine GPCR 0.0105 0.0265 0.0375
Echinococcus granulosus vesicular acetylcholine transporter 0.2039 0.7061 1
Brugia malayi Dopamine receptor protein 1 0.0105 0.0265 0.0265
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0105 0.0265 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Echinococcus granulosus Protein patched homolog 1 0.0044 0.0049 0.007
Echinococcus multilocularis muscleblind protein 0.0156 0.0443 0.0627
Schistosoma mansoni biogenic amine (5HT) receptor 0.0105 0.0265 0.0375
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2039 0.7061 1
Schistosoma mansoni amine GPCR 0.0316 0.1006 0.1425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0221 0.0313
Echinococcus granulosus serotonin receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis geminin 0.0164 0.0471 0.0667
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0221 0.0313
Schistosoma mansoni hypothetical protein 0.011 0.0281 0.0398
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0221 0.0313
Echinococcus multilocularis G protein coupled receptor 139 0.0105 0.0265 0.0375
Brugia malayi vesicular acetylcholine transporter unc-17 0.2039 0.7061 0.7061
Schistosoma mansoni hypothetical protein 0.0043 0.0044 0.0062
Echinococcus multilocularis G-protein coupled receptor, putative 0.0105 0.0265 0.0375
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.1024 0.1024
Schistosoma mansoni biogenic amine (5HT) receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.0281 0.0398
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0221 0.0221
Echinococcus multilocularis neuropeptide receptor A26 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi Serotonin receptor 0.0105 0.0265 0.0265
Plasmodium falciparum importin beta, putative 0.003 0 0.5
Echinococcus granulosus somatostatin receptor 0.0105 0.0265 0.0375
Brugia malayi Calcitonin receptor-like protein seb-1 0.0348 0.1116 0.1116
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0105 0.0265 0.0375
Schistosoma mansoni amine GPCR 0.0105 0.0265 0.0375
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0105 0.0265 0.0265
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0105 0.0265 0.0375
Echinococcus granulosus neuropeptide receptor A26 0.0105 0.0265 0.0375
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0105 0.0265 0.0375
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0105 0.0265 0.0265
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis muscleblind protein 1 0.0156 0.0443 0.0627
Brugia malayi neuropeptide F receptor 0.0105 0.0265 0.0265
Brugia malayi G protein-coupled receptor 0.0105 0.0265 0.0265
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni amine GPCR 0.0105 0.0265 0.0375
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0105 0.0265 0.0375
Brugia malayi putative neuropeptide receptor NPR1 0.0105 0.0265 0.0265
Brugia malayi G protein-coupled receptor F59B2.13 0.0105 0.0265 0.0265
Schistosoma mansoni neuropeptide F-like receptor 0.0105 0.0265 0.0375
Brugia malayi Dopamine receptor protein 2 0.0105 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis neuropeptides capa receptor 0.0105 0.0265 0.0375
Brugia malayi CHE-14 protein 0.0044 0.0049 0.0049
Echinococcus granulosus biogenic amine 5HT receptor 0.0105 0.0265 0.0375
Schistosoma mansoni opsin-like receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus tm gpcr rhodopsin 0.0105 0.0265 0.0375
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0105 0.0265 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Trypanosoma brucei C-8 sterol isomerase, putative 0.2875 1 1
Brugia malayi ORL1-like opioid receptor 0.0105 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis neuropeptide FF receptor 2 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0044 0.0049 0.0049
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus sex peptide receptor 0.0105 0.0265 0.0375
Brugia malayi Latrophilin receptor protein 2 0.011 0.0281 0.0281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0221 0.0313
Echinococcus multilocularis g protein coupled receptor 0.0105 0.0265 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus Niemann Pick C1 protein 0.0103 0.0256 0.0362
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) neuropeptide F receptor 0.0105 0.0265 0.0265
Echinococcus multilocularis fmrfamide receptor 0.0105 0.0265 0.0375
Echinococcus granulosus geminin 0.0164 0.0471 0.0667
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0105 0.0265 0.0265
Loa Loa (eye worm) G-protein coupled receptor 0.0105 0.0265 0.0265
Echinococcus granulosus dro:myosuppressin receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.0281 0.0398
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Schistosoma mansoni neuropeptide receptor 0.0105 0.0265 0.0375
Schistosoma mansoni adenoreceptor 0.0105 0.0265 0.0375
Echinococcus multilocularis dro:myosuppressin receptor 0.0105 0.0265 0.0375
Schistosoma mansoni opsin-like receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus G protein coupled receptor 139 0.0105 0.0265 0.0375
Plasmodium vivax importin-beta 2, putative 0.003 0 0.5
Echinococcus multilocularis neuropeptide Y receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis protein patched 0.0044 0.0049 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus hypothetical protein 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0105 0.0265 0.0265
Echinococcus granulosus neuropeptide receptor 0.0105 0.0265 0.0375
Schistosoma mansoni neuropeptide receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis neuropeptide receptor 0.0105 0.0265 0.0375
Schistosoma mansoni neuropeptide f receptor 76f 0.0105 0.0265 0.0375
Echinococcus granulosus snurportin 1 0.0322 0.1024 0.1451
Loa Loa (eye worm) hypothetical protein 0.011 0.0281 0.0281
Schistosoma mansoni hypothetical protein 0.0238 0.073 0.1033
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0105 0.0265 0.0375
Brugia malayi latrophilin 2 splice variant baaae 0.0238 0.073 0.073
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Trypanosoma cruzi C-8 sterol isomerase, putative 0.2875 1 0.5
Echinococcus granulosus fmrfamide receptor 0.0105 0.0265 0.0375
Echinococcus granulosus neuropeptide Y receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi Dopamine receptor 0.0105 0.0265 0.0265
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0105 0.0265 0.0375
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0054 0.0084 0.0084
Echinococcus granulosus sterol regulatory element binding protein 0.0044 0.0049 0.007
Schistosoma mansoni biogenic amine receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis GPCR, family 2 0.011 0.0281 0.0398
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus neuropeptide s receptor 0.0105 0.0265 0.0375
Schistosoma mansoni histamine h1 receptor 0.0105 0.0265 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.2875 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0105 0.0265 0.0265
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0049 0.5
Brugia malayi RNA, U transporter 1 0.0086 0.0195 0.0195
Echinococcus multilocularis somatostatin receptor 0.0105 0.0265 0.0375
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0221 0.0313
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0221 0.0313
Echinococcus granulosus neuropeptide receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus 7TM GPCR rhodopsin 0.0105 0.0265 0.0375
Schistosoma mansoni opsin-like receptor 0.0105 0.0265 0.0375
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0103 0.0256 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0105 0.0265 0.0375
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0105 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0105 0.0265 0.0375
Echinococcus multilocularis serotonin receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0105 0.0265 0.0375
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0105 0.0265 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus allatostatin A receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus orexin receptor type 2 0.0105 0.0265 0.0375
Echinococcus multilocularis allatostatin A receptor 0.0105 0.0265 0.0375
Echinococcus granulosus g protein coupled receptor 0.0105 0.0265 0.0375
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0105 0.0265 0.0375
Toxoplasma gondii HEAT repeat-containing protein 0.003 0 0.5
Echinococcus granulosus expressed conserved protein 0.0097 0.0234 0.0331
Brugia malayi Serotonin receptor 0.0105 0.0265 0.0265
Echinococcus multilocularis snurportin 1 0.0322 0.1024 0.1451
Loa Loa (eye worm) hypothetical protein 0.0348 0.1116 0.1116
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0221 0.0313
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni alpha-1 adrenergic receptor 0.0105 0.0265 0.0375
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0105 0.0265 0.0375
Echinococcus granulosus g protein coupled receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.0281 0.0398
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni neuropeptide receptor 0.0105 0.0265 0.0375
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) TYRA-2 protein 0.0105 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.011 0.0281 0.0398
Brugia malayi putative neuropeptide receptor 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0238 0.073 0.073
Schistosoma mansoni hypothetical protein 0.0043 0.0044 0.0062
Schistosoma mansoni hypothetical protein 0.011 0.0281 0.0398
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0105 0.0265 0.0375
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0393 0.1275 0.1805
Echinococcus multilocularis rhodopsin orphan GPCR 0.0105 0.0265 0.0375
Echinococcus granulosus neuropeptide FF receptor 2 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0105 0.0265 0.0375
Schistosoma mansoni growth hormone secretagogue receptor 0.0105 0.0265 0.0375
Schistosoma mansoni neuropeptide F-like receptor 0.0105 0.0265 0.0375
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0348 0.1116 0.1116
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0105 0.0265 0.0265
Brugia malayi RE15519p 0.0105 0.0265 0.0265
Brugia malayi follicle stimulating hormone receptor 0.0105 0.0265 0.0265
Echinococcus granulosus Niemann Pick C1 protein 0.0147 0.0411 0.0582
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0043 0.0044 0.0062
Echinococcus multilocularis g protein coupled receptor 0.0105 0.0265 0.0375
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0105 0.0265 0.0375
Echinococcus multilocularis Niemann Pick C1 protein 0.0103 0.0256 0.0362
Echinococcus multilocularis serotonin receptor 0.0105 0.0265 0.0375
Echinococcus granulosus GPCR family 2 0.011 0.0281 0.0398
Brugia malayi hypothetical protein 0.0105 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0156 0.0443 0.0443
Loa Loa (eye worm) melatonin receptor type 1A 0.0105 0.0265 0.0265
Schistosoma mansoni myosin xvIII 0.0105 0.0265 0.0375
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2039 0.7061 0.7061
Schistosoma mansoni hypothetical protein 0.0164 0.0471 0.0667
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0105 0.0265 0.0375
Loa Loa (eye worm) hypothetical protein 0.0105 0.0265 0.0265

Activities

Activity type Activity value Assay description Source Reference
Delta Tm (binding) = 3.1 degrees C Binding affinity to His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells assessed as change in melting temperature at 50 uM after 30 mins by SYPRO orange dye based thermal stability shift assay ChEMBL. 27460668
Inhibition (binding) = -16.6 % Displacement of 1,8-ANS from His6-tagged FABP4 (unknown origin) expressed in Escherichia coli BL21(DE3) cells at 25 uM by fluorescence assay relative to control ChEMBL. 27460668

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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