Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0067 | 0 | 0.5 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0142 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0087 | 0.2691 | 1 |
Plasmodium falciparum | plasmepsin X | 0.0087 | 0.2691 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0087 | 0.2691 | 1 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0067 | 0 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0067 | 0 | 0.5 |
Plasmodium vivax | aspartyl protease, putative | 0.0087 | 0.2691 | 1 |
Plasmodium falciparum | plasmepsin IX | 0.0087 | 0.2691 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0067 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
KI_MICROM (functional) | > 44.3 um | PUBCHEM_BIOASSAY: Formylpeptide Receptor (FPR) Ligand Structure Activity Relationship (SAR) Analysis: Dose Response Assay. (Class of assay: confirmatory) [Related pubchem assays: 519, 520, 440, 699, 441 ] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.