Detailed information for compound 802483

Basic information

Technical information
  • TDR Targets ID: 802483
  • Name: (2E)-2-[(2-methoxyphenyl)methylidene]-6-[(4-p ropoxyphenyl)methyl]-[1,3]thiazolo[3,2-b][1,2 ,4]triazine-3,7-dione
  • MW: 439.527 | Formula: C23H25N3O4S
  • H donors: 0 H acceptors: 2 LogP: 4.59 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCOc1ccc(cc1)CC1NN2C(NC1=O)S/C(=C/c1ccccc1OC)/C2=O
  • InChi: 1S/C23H21N3O4S/c1-3-12-30-17-10-8-15(9-11-17)13-18-21(27)24-23-26(25-18)22(28)20(31-23)14-16-6-4-5-7-19(16)29-2/h4-11,14H,3,12-13H2,1-2H3/b20-14+
  • InChiKey: NNUNRVOIWVHRGD-XSFVSMFZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2E)-2-[(2-methoxyphenyl)methylene]-6-[(4-propoxyphenyl)methyl]thiazolo[3,2-b][1,2,4]triazine-3,7-dione
  • (2E)-2-(2-methoxybenzylidene)-6-(4-propoxybenzyl)thiazolo[3,2-b][1,2,4]triazine-3,7-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0153 0.4134 0.6783
Onchocerca volvulus 0.0243 0.6852 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0048 0.0934 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0129 0.3377 1
Brugia malayi latrophilin 2 splice variant baaae 0.0105 0.2658 0.4463
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0934 0.1359
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0291 0.2855
Mycobacterium tuberculosis Probable dehydrogenase 0.0116 0.2985 0.8837
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0542 0.1167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0635 0.0921
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.04 0.0396
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0542 0.0538
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0048 0.0934 0.0931
Treponema pallidum NADH oxidase 0.0018 0.0004 0.5
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0366 0.0362
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.1011 0.1007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0542 0.0538
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.04 0.0396
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0004 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.026 0.0375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0048 0.0934 0.9241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.026 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0345 0.0498
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0048 0.0934 0.0931
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0116 0.2985 0.8837
Loa Loa (eye worm) phosphatidylinositol 3 0.0048 0.0934 0.1135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0635 0.0921
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0129 0.3377 1
Schistosoma mansoni hypothetical protein 0.0169 0.4617 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0004 0.5
Echinococcus granulosus geminin 0.0169 0.4617 0.4615
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.002 0.0078 0.0738
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0345 0.0498
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.1011 0.2985
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0048 0.0934 0.9241
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0018 0.0004 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.026 0.0375
Schistosoma mansoni hypothetical protein 0.0049 0.0945 0.2041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0259 0.0373
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0116 0.2985 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Leishmania major hypothetical protein, conserved 0.0027 0.0291 0.2855
Loa Loa (eye worm) RNA binding protein 0.0136 0.3595 0.5833
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0635 0.0921
Plasmodium vivax glutathione reductase, putative 0.0051 0.1011 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.04 0.0859
Loa Loa (eye worm) hypothetical protein 0.0049 0.0945 0.1155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0635 0.0921
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.04 0.0859
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0291 0.2855
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0945 0.1155
Plasmodium falciparum glutathione reductase 0.0051 0.1011 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0048 0.0934 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0048 0.0934 0.9241
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0038 0.0636 0.6277
Schistosoma mansoni hypothetical protein 0.0049 0.0945 0.2041
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.3595 0.6036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0934 0.1359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Toxoplasma gondii thioredoxin reductase 0.0051 0.1011 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.04 0.0396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0934 0.1359
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0129 0.3377 1
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0291 0.2855
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.1011 0.1007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0945 0.1587
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0004 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0345 0.0498
Loa Loa (eye worm) hypothetical protein 0.0031 0.04 0.0192
Mycobacterium tuberculosis Probable reductase 0.0116 0.2985 0.8837
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.0004 0.5
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0004 0.5
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0116 0.2985 0.8837
Brugia malayi Pre-SET motif family protein 0.0213 0.5956 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0945 0.0942
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.042 0.0609
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.072 0.1046
Trypanosoma brucei trypanothione reductase 0.0051 0.1011 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0291 0.2855
Leishmania major trypanothione reductase 0.0051 0.1011 1
Echinococcus multilocularis tar DNA binding protein 0.0136 0.3595 0.3593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.1011 0.127
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0945 0.0942
Schistosoma mansoni tar DNA-binding protein 0.0136 0.3595 0.7785
Loa Loa (eye worm) hypothetical protein 0.0105 0.2658 0.4178
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.5956 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0559 0.5514
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0048 0.0934 0.9241
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.04 0.0859
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0129 0.3377 1
Brugia malayi RNA binding protein 0.0136 0.3595 0.6036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0153 0.4134 0.6941
Onchocerca volvulus 0.0051 0.1011 0.0947
Brugia malayi hypothetical protein 0.0035 0.0542 0.091
Plasmodium falciparum thioredoxin reductase 0.0051 0.1011 1
Echinococcus granulosus GPCR family 2 0.0049 0.0945 0.0942
Brugia malayi hypothetical protein 0.0027 0.0291 0.0489
Schistosoma mansoni hypothetical protein 0.0049 0.0945 0.2041
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0945 0.0942
Trypanosoma cruzi target of rapamycin kinase 3 0.0038 0.0636 0.6277
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0153 0.4134 0.6941
Loa Loa (eye worm) TAR-binding protein 0.0136 0.3595 0.5833
Brugia malayi Pre-SET motif family protein 0.0031 0.04 0.0672
Schistosoma mansoni tar DNA-binding protein 0.0136 0.3595 0.7785
Trichomonas vaginalis set domain proteins, putative 0.0243 0.6852 1
Schistosoma mansoni tar DNA-binding protein 0.0136 0.3595 0.7785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0336 0.0485
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1011 0.2184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0336 0.0485
Echinococcus multilocularis GPCR, family 2 0.0049 0.0945 0.0942
Loa Loa (eye worm) glutathione reductase 0.0051 0.1011 0.127
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.1011 1
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0038 0.0636 0.6277
Loa Loa (eye worm) hypothetical protein 0.0051 0.1011 0.1271
Schistosoma mansoni tar DNA-binding protein 0.0136 0.3595 0.7785
Plasmodium vivax SET domain protein, putative 0.0031 0.04 0.3936
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.04 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0291 0.2855
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0048 0.0934 0.9241
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.3595 0.5833
Schistosoma mansoni tar DNA-binding protein 0.0136 0.3595 0.7785
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0635 0.0921
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.026 0.0375
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0048 0.0934 0.9241
Schistosoma mansoni hypothetical protein 0.0035 0.0542 0.1167
Giardia lamblia GTOR 0.0048 0.0934 1
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0945 0.1587
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0004 0.5
Echinococcus multilocularis geminin 0.0169 0.4617 0.4615
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0934 0.1569
Brugia malayi TAR-binding protein 0.0136 0.3595 0.6036
Schistosoma mansoni hypothetical protein 0.0169 0.4617 1
Brugia malayi Thioredoxin reductase 0.0051 0.1011 0.1697
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0259 0.0373
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.04 0.3936
Echinococcus multilocularis tumor protein p63 0.0346 1 1
Echinococcus granulosus tar DNA binding protein 0.0136 0.3595 0.3593
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0259 0.0373
Schistosoma mansoni hypothetical protein 0.0105 0.2658 0.5753
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0162 0.1575
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0291 0.2855
Brugia malayi glutathione reductase 0.0051 0.1011 0.1697
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0945 0.0942
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0048 0.0934 0.2017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0452 0.0655
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0153 0.4134 0.6783
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.1011 1
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0291 0.2855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0559 0.0811
Schistosoma mansoni hypothetical protein 0.0049 0.0945 0.2041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0116 0.2985 0.8837

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.