Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | squalene monooxygenase, putative | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0072 | 0.2537 | 0.3429 |
Echinococcus granulosus | DNA topoisomerase 1 | 0.019 | 0.7399 | 1 |
Brugia malayi | DNA topoisomerase I | 0.019 | 0.7399 | 1 |
Plasmodium vivax | topoisomerase I, putative | 0.019 | 0.7399 | 0.5 |
Leishmania major | DNA topoisomerase IB, large subunit | 0.0142 | 0.5436 | 0.4599 |
Onchocerca volvulus | 0.0074 | 0.2615 | 1 | |
Trypanosoma cruzi | DNA topoisomerase IB, large subunit, putative | 0.0142 | 0.5436 | 0.4599 |
Loa Loa (eye worm) | DNA topoisomerase I | 0.019 | 0.7399 | 1 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0142 | 0.5436 | 0.7347 |
Echinococcus multilocularis | DNA topoisomerase 1 | 0.019 | 0.7399 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2203 | 0.2977 |
Schistosoma mansoni | DNA topoisomerase type I | 0.019 | 0.7399 | 1 |
Trypanosoma brucei | DNA topoisomerase IB, large subunit | 0.0142 | 0.5436 | 0.4599 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.2527 | 0.3416 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0072 | 0.2537 | 0.3429 |
Toxoplasma gondii | DNA topoisomerase I, putative | 0.019 | 0.7399 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.2615 | 0.3535 |
Plasmodium falciparum | topoisomerase I | 0.019 | 0.7399 | 0.5 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0064 | 0.2212 | 0.299 |
Onchocerca volvulus | 0.0071 | 0.2527 | 0.7864 | |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0253 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0064 | 0.2203 | 0.2977 |
Schistosoma mansoni | protein kinase C mu | 0.0072 | 0.2537 | 0.3429 |
Brugia malayi | C1-like domain containing protein | 0.0072 | 0.2537 | 0.3429 |
Schistosoma mansoni | DNA topoisomerase type I | 0.0142 | 0.5436 | 0.7347 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0253 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.