Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.00346094 | 0.00214847 | 0.00252978 |
Loa Loa (eye worm) | hypothetical protein | 0.00607038 | 0.110277 | 0.161833 |
Giardia lamblia | Kinesin-5 | 0.00363753 | 0.00946598 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.00363753 | 0.00946598 | 0.0138914 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.00735307 | 0.163429 | 0.239834 |
Loa Loa (eye worm) | PHD-finger family protein | 0.00346094 | 0.00214847 | 0.0031529 |
Plasmodium falciparum | kinesin-5 | 0.00363753 | 0.00946598 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.00363753 | 0.00946598 | 0.0310672 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0107622 | 0.304694 | 0.304694 |
Loa Loa (eye worm) | hypothetical protein | 0.0198537 | 0.681426 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.00857038 | 0.213871 | 0.25183 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.00363753 | 0.00946598 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.0275418 | 1 | 1 |
Echinococcus granulosus | peregrin | 0.00346094 | 0.00214847 | 0.00214847 |
Onchocerca volvulus | Alhambra homolog | 0.00346094 | 0.00214847 | 0.5 |
Echinococcus multilocularis | jumonji domain containing protein | 0.00516129 | 0.0726069 | 0.0726069 |
Echinococcus granulosus | kinesin family 1 | 0.0275418 | 1 | 1 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.00346094 | 0.00214847 | 0.00214847 |
Brugia malayi | Bromodomain containing protein | 0.00346094 | 0.00214847 | 0.00705124 |
Loa Loa (eye worm) | hypothetical protein | 0.00346094 | 0.00214847 | 0.0031529 |
Schistosoma mansoni | hypothetical protein | 0.0239042 | 0.84927 | 1 |
Echinococcus multilocularis | peregrin | 0.00346094 | 0.00214847 | 0.00214847 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.00346094 | 0.00214847 | 0.00214847 |
Brugia malayi | jmjC domain containing protein | 0.0107622 | 0.304694 | 1 |
Plasmodium vivax | kinesin-5 | 0.00363753 | 0.00946598 | 1 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0107622 | 0.304694 | 0.304694 |
Schistosoma mansoni | kinesin eg-5 | 0.00363753 | 0.00946598 | 0.011146 |
Brugia malayi | PHD-finger family protein | 0.00346094 | 0.00214847 | 0.00705124 |
Echinococcus granulosus | jumonji domain containing protein | 0.00516129 | 0.0726069 | 0.0726069 |
Entamoeba histolytica | kinesin, putative | 0.00363753 | 0.00946598 | 0.5 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.00346094 | 0.00214847 | 0.00252978 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 86 % | Hemolytic activity in human erythrocytes at 1 mM | ChEMBL. | 17079152 |
Hemolysis (functional) | = 62 % | Lysis of human erythrocytes at a concentration of 1 mM for 30 minutes at 37 degree C | ChEMBL. | 15027875 |
Hemolysis (functional) | = 62 % | Lysis of human erythrocytes at a concentration of 1 mM for 30 minutes at 37 degree C | ChEMBL. | 15027875 |
IC50 (functional) | > 10 uM | In vitro antimalarial activity against D2 strain of Plasmodium falciparum | ChEMBL. | 15027875 |
IC50 (functional) | > 10 uM | In vitro antimalarial activity against D2 strain of Plasmodium falciparum | ChEMBL. | 15027875 |
IC50 (functional) | = 250 uM | Growth inhibition of Candida albicans JRW#5 | ChEMBL. | 17079152 |
IC50 (functional) | = 250 uM | Growth inhibition of Candida albicans JRW#5 | ChEMBL. | 17079152 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 15027875 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.