Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 0.1624 | 0.1624 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0182 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 0.1624 | 0.1827 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0053 | 0.1624 | 0.1827 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0053 | 0.1624 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Echinococcus granulosus | geminin | 0.0165 | 0.8888 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1331 | 0.1331 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0053 | 0.1624 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Echinococcus multilocularis | geminin | 0.0165 | 0.8888 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.1331 | 0.1331 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.1496 | 0.1496 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0053 | 0.1624 | 0.1827 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0053 | 0.1624 | 0.1827 |
Schistosoma mansoni | thyroid hormone receptor | 0.0053 | 0.1624 | 0.1827 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0053 | 0.1624 | 0.1827 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0051 | 0.1496 | 0.1496 |
Brugia malayi | Blistered cuticle protein 3 | 0.0051 | 0.1496 | 0.1496 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0182 | 1 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1215 | 0.1367 |
Brugia malayi | Peroxidasin | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Echinococcus multilocularis | peroxidasin | 0.0051 | 0.1496 | 0.1683 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0053 | 0.1624 | 0.1827 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0053 | 0.1624 | 0.1827 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0335 | 0.0377 |
Onchocerca volvulus | 0.0053 | 0.1624 | 0.0151 | |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.1496 | 0.1496 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0126 | 0.6357 | 0.5 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.1496 | 0.1496 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0053 | 0.1624 | 0.1827 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1215 | 0.1367 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.8888 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.1496 | 0.1496 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0053 | 0.1624 | 0.1827 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.1496 | 0.1496 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.0335 | 0.0335 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0053 | 0.1624 | 0.1624 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1215 | 0.1367 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.1215 | 0.1367 |
Echinococcus granulosus | FTZ F1 alpha | 0.0053 | 0.1624 | 0.1827 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0053 | 0.1624 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Brugia malayi | steroid hormone receptor | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0053 | 0.1624 | 0.1624 |
Schistosoma mansoni | peroxidasin | 0.0051 | 0.1496 | 0.1683 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0053 | 0.1624 | 0.1624 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0053 | 0.1624 | 0.1827 |
Echinococcus granulosus | peroxidasin | 0.0051 | 0.1496 | 0.1683 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0053 | 0.1624 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1215 | 0.1215 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0053 | 0.1624 | 0.1624 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0053 | 0.1624 | 0.1827 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Brugia malayi | nuclear hormone receptor | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0335 | 0.0335 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.1331 | 0.1331 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1215 | 0.1367 |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0182 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0053 | 0.1624 | 0.1624 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 0.1624 | 0.1827 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.1825 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.1825 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 0.1624 | 0.1827 |
Mycobacterium ulcerans | phosphotyrosine protein phosphatase PtpA | 0.0182 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0053 | 0.1624 | 0.1624 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0053 | 0.1624 | 0.0151 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0053 | 0.1624 | 0.1827 |
Trypanosoma brucei | low molecular weight protein tyrosine phosphatase, putative | 0.0056 | 0.1825 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0053 | 0.1624 | 0.1827 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0053 | 0.1624 | 0.1624 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.34 | 0.34 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1215 | 0.1215 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0182 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0053 | 0.1624 | 0.1827 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.1215 | 0.1367 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0053 | 0.1624 | 0.1624 |
Schistosoma mansoni | coup transcription factor | 0.0053 | 0.1624 | 0.1827 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0.1825 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.1331 | 0.1331 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0053 | 0.1624 | 0.1624 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0053 | 0.1624 | 0.0151 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.8888 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1215 | 0.1367 |
Brugia malayi | Animal haem peroxidase family protein | 0.0051 | 0.1496 | 0.1496 |
Entamoeba histolytica | protein tyrosine phosphatase, putative | 0.0182 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0051 | 0.1496 | 0.1683 |
Onchocerca volvulus | 0.0182 | 1 | 1 | |
Trichomonas vaginalis | low molecular weight protein-tyrosine-phosphatase, putative | 0.0182 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0053 | 0.1624 | 0.1827 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0182 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0053 | 0.1624 | 0.1827 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0053 | 0.1624 | 0.1827 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0053 | 0.1624 | 0.0151 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0053 | 0.1624 | 0.1827 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0053 | 0.1624 | 0.1827 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0053 | 0.1624 | 0.1827 |
Schistosoma mansoni | nuclear hormone receptor | 0.0053 | 0.1624 | 0.1827 |
Brugia malayi | hypothetical protein | 0.0051 | 0.1496 | 0.1496 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0053 | 0.1624 | 0.1827 |
Trichomonas vaginalis | low molecular weight protein tyrosine phosphatase, putative | 0.0182 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1624 | 0.1624 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0053 | 0.1624 | 0.1624 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
RBA (binding) | = 1.2 | Relative Binding affinity(RBA) to human progesterone receptor(PR) compared to PF1092A; (RBA= IC50 of PF1092A/ IC50 of test compound at human PR) | ChEMBL. | 10406651 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.