Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrix metalloproteinase | 0.0145 | 0.097 | 0.0619 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0322 | 0.3682 | 0.7128 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.097 | 0.0619 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.1276 | 0.1276 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0734 | 1 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0322 | 0.3682 | 0.3437 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0281 | 0.3047 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0393 | 0.4775 | 1 |
Brugia malayi | Matrixin family protein | 0.0145 | 0.097 | 0.0619 |
Brugia malayi | Dihydrofolate reductase | 0.0734 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0734 | 1 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0216 | 0.2063 | 0.2063 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.097 | 0.0619 |
Onchocerca volvulus | 0.0165 | 0.1276 | 0.0803 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0734 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.0734 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0281 | 0.3047 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0281 | 0.3047 | 0.5 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0177 | 0.1456 | 0.1123 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0281 | 0.3047 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0145 | 0.097 | 0.0619 |
Loa Loa (eye worm) | hypothetical protein | 0.0216 | 0.2063 | 0.1754 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0734 | 1 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0281 | 0.3047 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0734 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0381 | 0.4595 | 0.4385 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0281 | 0.3047 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0381 | 0.4595 | 0.4385 |
Brugia malayi | Matrixin family protein | 0.0145 | 0.097 | 0.0619 |
Brugia malayi | Hemopexin family protein | 0.0165 | 0.1276 | 0.0936 |
Echinococcus granulosus | dihydrofolate reductase | 0.0734 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.1456 | 0.1123 |
Brugia malayi | Matrixin family protein | 0.0145 | 0.097 | 0.0619 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0734 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.