Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase alpha catalytic subunit, putative | 0.0028 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0187 | 0.4861 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0168 | 0.4281 | 0.4281 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0168 | 0.4281 | 0.4281 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0354 | 1 | 1 |
Plasmodium vivax | DNA polymerase alpha, putative | 0.0052 | 0.0736 | 0.5 |
Trichomonas vaginalis | DNA polymerase II, putative | 0.0028 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0057 | 0.0893 | 1 |
Onchocerca volvulus | DNA polymerase alpha catalytic subunit homolog | 0.0088 | 0.1843 | 0.5 |
Brugia malayi | DNA polymerase I family protein | 0.0116 | 0.2689 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2689 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0028 | 0.0003 | 0.0003 |
Trypanosoma brucei | RNA helicase, putative | 0.0097 | 0.2119 | 0.2119 |
Echinococcus granulosus | DNA polymerase subunit gamma | 0.0116 | 0.2689 | 1 |
Giardia lamblia | DNA polymerase alpha subunit A | 0.0054 | 0.0806 | 0.5 |
Echinococcus multilocularis | hypothetical protein | 0.0116 | 0.2689 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.005 | 0.0669 | 0.0669 |
Schistosoma mansoni | hypothetical protein | 0.0097 | 0.2119 | 0.6399 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0028 | 0.0003 | 0.0003 |
Trypanosoma brucei | retrotransposon hot spot protein 4 (RHS4), interrupted | 0.0028 | 0.0003 | 0.0003 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0168 | 0.4281 | 0.4281 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0061 | 0.1003 | 0.1003 |
Mycobacterium ulcerans | hypothetical protein | 0.0187 | 0.4861 | 0.5 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0669 | 0.0669 |
Trypanosoma brucei | ingi protein (ORF1) | 0.0028 | 0.0003 | 0.0003 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.005 | 0.0669 | 0.0669 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0354 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.005 | 0.0669 | 0.0669 |
Trypanosoma brucei | unspecified product | 0.0028 | 0.0003 | 0.0003 |
Schistosoma mansoni | DNA polymerase gamma | 0.0116 | 0.2689 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0354 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.