Detailed information for compound 810476

Basic information

Technical information
  • TDR Targets ID: 810476
  • Name: N,N-dimethyl-4-[(Z)-1,2,4-triazol-4-yliminome thyl]aniline
  • MW: 202.256 | Formula: C11H14N4
  • H donors: 0 H acceptors: 2 LogP: 1.28 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc(cc1)C=N1C=NN=C1)C
  • InChi: 1S/C11H13N5/c1-15(2)11-5-3-10(4-6-11)7-14-16-8-12-13-9-16/h3-9H,1-2H3/b14-7-
  • InChiKey: YDHQRSFAZYRBTA-AUWJEWJLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • dimethyl-[4-[(Z)-1,2,4-triazol-4-yliminomethyl]phenyl]amine
  • ZINC00242663

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0224 0.6641 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0118 0.2719 0.2463
Plasmodium vivax DNA polymerase alpha, putative 0.0104 0.2208 0.1675
Brugia malayi DNA polymerase alpha catalytic subunit 0.0104 0.2208 0.2964
Trypanosoma brucei unspecified product 0.0061 0.0604 0.0273
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0224 0.6641 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0113 0.2523 0.226
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.008 0.1316 0.101
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.008 0.1316 0.1548
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.008 0.1316 0.1548
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0224 0.6641 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0132 0.3212 0.5
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.008 0.1316 0.1548
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0224 0.6641 0.6523
Treponema pallidum ribonuclease H (rnhA) 0.0054 0.034 0.5
Mycobacterium ulcerans hypothetical protein 0.0132 0.3212 0.5
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.018 0.5 0.6443
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.008 0.1316 0.1548
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0118 0.2719 0.329
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0087 0.1583 0.1719
Trichomonas vaginalis ribonuclease H1, putative 0.0054 0.034 0.0512
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.008 0.1316 0.1349
Trypanosoma brucei RNA helicase, putative 0.0315 1 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0087 0.1583 0.2384
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.008 0.1316 0.1548
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0224 0.6641 1
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.008 0.1316 0.1981
Trichomonas vaginalis DNA polymerase delta catalytic subunit, putative 0.008 0.1316 0.1981
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0061 0.0604 0.0273
Trypanosoma brucei hypothetical protein, conserved 0.0061 0.0604 0.0273
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0224 0.6641 0.5
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0054 0.034 0.5
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.008 0.1316 0.101
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.013 0.3147 0.4455
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0224 0.6641 0.8712
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0224 0.6641 1
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.008 0.1316 0.1349
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.008 0.1316 0.1548
Brugia malayi DNA polymerase family B containing protein 0.008 0.1316 0.1548
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0104 0.2208 0.2964
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.008 0.1316 0.1349
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.008 0.1316 0.101
Brugia malayi DNA polymerase delta catalytic subunit 0.0224 0.6641 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0224 0.6641 0.8712
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0224 0.6641 0.6523
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0118 0.2719 0.329
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0087 0.1583 0.1719
Trypanosoma brucei ingi protein (ORF1) 0.0061 0.0604 0.0273
Trichomonas vaginalis DNA polymerase II, putative 0.0087 0.1583 0.2384
Leishmania major mitochondrial DNA polymerase beta 0.025 0.7573 1
Onchocerca volvulus DNA polymerase homolog 0.008 0.1316 0.1548
Toxoplasma gondii DNA polymerase family B protein 0.008 0.1316 0.1548
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.025 0.7573 1
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0087 0.1583 0.1287
Loa Loa (eye worm) hypothetical protein 0.013 0.3147 0.4739
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0113 0.2523 0.3464
Giardia lamblia DNA polymerase alpha subunit A 0.0068 0.0881 0.0859
Trypanosoma brucei ingi protein (ORF1) 0.0061 0.0604 0.0273
Trypanosoma brucei mitochondrial DNA polymerase beta 0.025 0.7573 0.7488
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.008 0.1316 0.1548
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0224 0.6641 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.025 0.7573 1
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0113 0.2523 0.3464
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0224 0.6641 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.008 0.1316 0.101
Toxoplasma gondii DNA polymerase 0.0224 0.6641 1
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0224 0.6641 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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