Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | lipase containing protein, putative | 0.0729 | 1 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0422 | 0.0216 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0729 | 1 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0729 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0729 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0729 | 1 | 0.5 |
Loa Loa (eye worm) | lipase | 0.0729 | 1 | 0.5 |
Onchocerca volvulus | 0.0729 | 1 | 0.5 | |
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0729 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0729 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0729 | 1 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0729 | 1 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0415 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.