Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | sn1 specific diacylglycerol lipase beta | 0.0852 | 1 | 0.5 |
Onchocerca volvulus | 0.0852 | 1 | 0.5 | |
Loa Loa (eye worm) | lipase | 0.0852 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0852 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0852 | 1 | 0.5 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0413 | 0.0149 | 0.5 |
Echinococcus granulosus | sn1 specific diacylglycerol lipase beta | 0.0852 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0852 | 1 | 0.5 |
Trichomonas vaginalis | lipase containing protein, putative | 0.0852 | 1 | 0.5 |
Trypanosoma brucei | lipase domain protein, putative | 0.0852 | 1 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0852 | 1 | 0.5 |
Mycobacterium tuberculosis | 4,9-DHSA hydrolase | 0.0407 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0852 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.