Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0233 | 0 | 0.5 |
Mycobacterium ulcerans | malate synthase G | 0.2295 | 1 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2295 | 1 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.0233 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE ISOCITRATE LYASE AceA (ISOCITRASE) (ISOCITRATASE) (ICL) | 0.1569 | 0.6478 | 0.5344 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 75 mg kg-1 | Antiviral activity against Forest virus (SFV) | ChEMBL. | 2999405 |
ED50 (functional) | > 400 mg kg-1 | Effective dose administered perorally againist Forest virus infected mice | ChEMBL. | 2999405 |
ED50 (functional) | > 400 mg kg-1 | Effective dose administered subcutaneously againist Forest virus infected mice | ChEMBL. | 2999405 |
Protection index (functional) | = 0.45 | Intraperitoneal administration against herpes simplex virus type-1 (HSV-1) infected mice | ChEMBL. | 2999405 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.