Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.966 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0636 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.966 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.966 | 0.966 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.966 | 0.966 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.966 | 0.5 |
Onchocerca volvulus | 0.006 | 1 | 0.5 | |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.006 | 1 | 1 |
Onchocerca volvulus | 0.006 | 1 | 0.5 | |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.966 | 0.5 |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.006 | 1 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.966 | 0.966 |
Onchocerca volvulus | 0.006 | 1 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0049 | 0 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.966 | 0.966 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.966 | 0.5 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.006 | 1 | 1 |
Onchocerca volvulus | 0.006 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.966 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.