Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0232 | 0.3962 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.3832 | 0.9673 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0547 | 1 | 0.5 |
Onchocerca volvulus | 0.0226 | 0.3832 | 0.7864 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0115 | 0.029 |
Brugia malayi | C1-like domain containing protein | 0.0226 | 0.3847 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0226 | 0.3847 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.3355 | 0.8468 |
Brugia malayi | Pleckstrin Homology Domain | 0.0032 | 0.0115 | 0.0299 |
Schistosoma mansoni | vav2 | 0.0032 | 0.0115 | 0.0299 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0226 | 0.3847 | 0.971 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.3962 | 1 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0032 | 0.0115 | 1 |
Echinococcus granulosus | myotubularin protein 13 | 0.0032 | 0.0115 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.3355 | 0.8468 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0226 | 0.3847 | 1 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0201 | 0.337 | 0.8504 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0547 | 1 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0547 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 20.36 uM | Dose affording 50% of maximum transactivation for ecdysone receptor from Bombyx mori (BmEcR) and a beta-galactosidase reporter gene in HEK-293 cell-line | ChEMBL. | 12749890 |
EC50 (functional) | = 20.36 uM | Dose affording 50% of maximum transactivation for ecdysone receptor from Bombyx mori (BmEcR) and a beta-galactosidase reporter gene in HEK-293 cell-line | ChEMBL. | 12749890 |
EC50 (functional) | = 33.3 uM | Dose affording 50% of maximum transactivation for ecdysone receptor from Choristoneura fumiferana (CfEcR) and a luciferase reporter gene in CHO cells | ChEMBL. | 12749890 |
EC50 (functional) | = 33.3 uM | Dose affording 50% of maximum transactivation for ecdysone receptor from Choristoneura fumiferana (CfEcR) and a luciferase reporter gene in CHO cells | ChEMBL. | 12749890 |
Ratio (functional) | = 0.09 | Ratio of maximum level of gene expression (ecdysone receptor and luciferase gene) of compound to maximum level of gene expression with GSTM-E expressed as RMFI | ChEMBL. | 12749890 |
Ratio (functional) | = 0.22 | Ratio of maximum level of gene expression (ecdysone receptor and beta-galactosidase receptor) of compound to maximum level of gene expression with GSTM-E expressed as RMFI | ChEMBL. | 12749890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.