Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | aspartyl protease ASP1 | 0.0058 | 0.1835 | 0.0169 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0064 | 0.2232 | 0.5 |
Plasmodium falciparum | plasmepsin IV | 0.0058 | 0.1835 | 1 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0172 | 0.987 | 0.987 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0058 | 0.1828 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1835 | 0.133 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0058 | 0.1828 | 0.9963 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0058 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0064 | 0.2232 | 0.2232 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0058 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0058 | 0.1828 | 0.9963 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0041 | 0.0582 | 0.0582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0058 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0058 | 0.1828 | 0.9963 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.0172 | 0.987 | 0.987 |
Brugia malayi | Cathepsin L-like precursor | 0.0041 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | cathepsin B | 0.0064 | 0.2232 | 0.1752 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0174 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | cysteine protease | 0.0058 | 0.1828 | 0.1323 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0058 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0064 | 0.2232 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0058 | 0.1835 | 0.0169 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0174 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0174 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0174 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0058 | 0.1835 | 0.1835 |
Loa Loa (eye worm) | hypothetical protein | 0.0174 | 1 | 1 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0064 | 0.2232 | 0.2232 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0058 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0058 | 0.1828 | 0.1323 |
Plasmodium vivax | plasmepsin IV, putative | 0.0058 | 0.1835 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0058 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin l1 | 0.0058 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0174 | 1 | 1 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.1828 | 0.1323 |
Echinococcus granulosus | cathepsin l1 | 0.0041 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0041 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0041 | 0.0582 | 0.2606 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0058 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin F homolog | 0.0058 | 0.1828 | 1 |
Echinococcus multilocularis | cathepsin d (lysosomal aspartyl protease) | 0.0058 | 0.1835 | 0.1835 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0041 | 0.0582 | 0.0582 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0058 | 0.1835 | 0.133 |
Plasmodium falciparum | plasmepsin I | 0.0058 | 0.1835 | 1 |
Onchocerca volvulus | 0.0058 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin L homolog | 0.0058 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0064 | 0.2232 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0058 | 0.1835 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0058 | 0.1835 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0058 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0058 | 0.1828 | 0.1323 |
Plasmodium vivax | vivapain-2 | 0.0058 | 0.1828 | 0.9963 |
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0058 | 0.1835 | 0.8219 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0064 | 0.2232 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0058 | 0.1828 | 0.9963 |
Onchocerca volvulus | Cathepsin L homolog | 0.0058 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0041 | 0.0582 | 0.2606 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0058 | 0.1828 | 0.1828 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0058 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | cathepsin L-like precursor | 0.0041 | 0.0582 | 0.0582 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0064 | 0.2232 | 1 |
Echinococcus granulosus | cathepsin b | 0.0174 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0174 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0174 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0174 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0064 | 0.2232 | 0.5 |
Echinococcus granulosus | cathepsin d lysosomal aspartyl protease | 0.0058 | 0.1835 | 0.1835 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cysteine protease | 0.0058 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0041 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0058 | 0.1828 | 0.1828 |
Plasmodium falciparum | plasmepsin II | 0.0058 | 0.1835 | 1 |
Toxoplasma gondii | cathepsin B | 0.0064 | 0.2232 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0041 | 0.0582 | 0.3182 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0058 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine protease, putative | 0.0058 | 0.1828 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0058 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0058 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0058 | 0.1828 | 0.8189 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.