Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.115 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | aurora B kinase | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0059 | 0 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.0211 | 0.1395 | 0.5 |
Plasmodium vivax | serine/threonine protein kinase 6, putative | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0059 | 0 | 0.5 |
Giardia lamblia | Aurora kinase | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0059 | 0 | 0.5 |
Plasmodium falciparum | serine/threonine protein kinase, putative | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0059 | 0 | 0.5 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0059 | 0 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0211 | 0.1395 | 1 |
Leishmania major | protein kinase, putative | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | protein kinase , putative | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | aurora kinase A | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0059 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.115 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.115 | 1 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0 | 0.5 |
Brugia malayi | serine/threonine kinase 12 | 0.0059 | 0 | 0.5 |
Loa Loa (eye worm) | AUR protein kinase | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.0059 | 0 | 0.5 |
Echinococcus multilocularis | aurora kinase A | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | aurora B kinase, putative | 0.0059 | 0 | 0.5 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0059 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.