Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0072 | 0.0313 | 1 |
Onchocerca volvulus | 0.0033 | 0.0098 | 0.5 | |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0157 | 0.5008 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0157 | 0.5 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0072 | 0.0313 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0095 | 0.3034 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0036 | 0.1028 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0072 | 0.0313 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0157 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0017 | 0.0017 | 0.0535 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.0098 | 0.3136 |
Echinococcus multilocularis | musashi | 0.0033 | 0.0098 | 0.3136 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0016 | 0.0007 | 0.0237 |
Echinococcus granulosus | lamin | 0.0033 | 0.0098 | 0.3136 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0157 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.0098 | 0.3136 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0021 | 0.0036 | 0.1145 |
Schistosoma mansoni | lamin | 0.0033 | 0.0098 | 0.2814 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.0098 | 0.3136 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0079 | 0.0349 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0017 | 0.0535 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.0287 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0068 | 0.0287 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0157 | 0.4494 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.0098 | 0.3136 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0098 | 0.3136 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.0098 | 0.3136 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0157 | 0.4494 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0072 | 0.0313 | 1 |
Schistosoma mansoni | lamin | 0.0033 | 0.0098 | 0.2814 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 0.187 | 1 | 0.5 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.0098 | 0.2814 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0016 | 0.0007 | 0.0237 |
Onchocerca volvulus | 0.0033 | 0.0098 | 0.5 | |
Schistosoma mansoni | voltage-gated potassium channel | 0.0079 | 0.0349 | 1 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0021 | 0.0036 | 0.1145 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0157 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.0021 | 0.0036 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0036 | 0.1145 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0007 | 0.0237 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0157 | 0.5008 |
Echinococcus multilocularis | voltage gated potassium channel | 0.0021 | 0.0036 | 0.1145 |
Echinococcus granulosus | voltage gated potassium channel | 0.0021 | 0.0036 | 0.1145 |
Echinococcus multilocularis | lamin | 0.0033 | 0.0098 | 0.3136 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0157 | 0.5008 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0004 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0063 | 0.0262 | 0.8354 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0021 | 0.0036 | 0.1028 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.0098 | 0.3136 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.0098 | 0.3136 |
Mycobacterium ulcerans | histidinol dehydrogenase | 0.187 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.