Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | pantothenate kinase 3 | Starlite/ChEMBL | References |
Homo sapiens | pantothenate kinase 2 | Starlite/ChEMBL | References |
Homo sapiens | pantothenate kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | pantothenate kinase, putative | 0.0282 | 1 | 1 |
Trypanosoma brucei | pantothenate kinase subunit, putative | 0.0282 | 1 | 0.5 |
Plasmodium falciparum | pantothenate kinase 1, putative | 0.0282 | 1 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.0282 | 1 | 1 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0282 | 1 | 0.5 |
Echinococcus granulosus | pantothenate kinase 4 | 0.0282 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0282 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0282 | 1 | 1 |
Plasmodium vivax | pantothenate kinase, putative | 0.0282 | 1 | 1 |
Toxoplasma gondii | fumble protein | 0.0282 | 1 | 1 |
Schistosoma mansoni | pantothenate kinase | 0.0282 | 1 | 1 |
Trypanosoma cruzi | pantothenate kinase subunit, putative | 0.0282 | 1 | 0.5 |
Echinococcus multilocularis | pantothenate kinase 4 | 0.0282 | 1 | 1 |
Leishmania major | pantothenate kinase subunit, putative | 0.0282 | 1 | 0.5 |
Entamoeba histolytica | pantothenate kinase 1, putative | 0.0282 | 1 | 0.5 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0282 | 1 | 1 |
Trichomonas vaginalis | pantothenate kinase, putative | 0.0282 | 1 | 1 |
Onchocerca volvulus | Fumble homolog | 0.0282 | 1 | 1 |
Giardia lamblia | Pantothenate kinase 4 | 0.0282 | 1 | 0.5 |
Loa Loa (eye worm) | pantothenate kinase | 0.0282 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibition of purified human Pank3 using d-[1-14C]pantothenate as substrate after 10 mins by radiochemical enzyme assay | ChEMBL. | 25569308 |
IC50 (binding) | = 70 nM | Inhibition of purified human Pank1beta using d-[1-14C]pantothenate as substrate after 10 mins by radiochemical enzyme assay | ChEMBL. | 25569308 |
IC50 (binding) | = 92 nM | Inhibition of purified human Pank2 using d-[1-14C]pantothenate as substrate after 10 mins by radiochemical enzyme assay | ChEMBL. | 25569308 |
IC50 (binding) | = 0.14 uM | Inhibition of Pank1beta (unknown origin) by Kinase Glo HTS assay | ChEMBL. | 25569308 |
IC50 (binding) | = 0.36 uM | Inhibition of Pank3 (unknown origin) by Kinase Glo HTS assay | ChEMBL. | 25569308 |
Kapp (binding) | = 0.3 uM | Binding affinity to purified human Pank3 assessed as thermal stabilization by thermal shift assay in presence of 2 mM ATP/Mg2+ | ChEMBL. | 25569308 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.