Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0138 | 0.2344 | 0.2344 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0243 | 0.9844 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0159 | 0.3887 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0159 | 0.3887 | 0.3788 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0159 | 0.3887 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0 | 0.5 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0243 | 0.9844 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0159 | 0.3887 | 0.3788 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0243 | 0.9844 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0159 | 0.3887 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.0243 | 0.9844 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0159 | 0.3887 | 0.5 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0243 | 0.9844 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0159 | 0.3887 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0159 | 0.3887 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0159 | 0.3887 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0159 | 0.3887 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0159 | 0.3887 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0105 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.