Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0909 | 0.3387 | 0.5347 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.1092 | 0.5286 | 0.8343 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1547 | 1 | 0.5 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.1193 | 0.6335 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0909 | 0.3387 | 0.5347 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0909 | 0.3387 | 0.3387 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.1193 | 0.6335 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0791 | 0.2161 | 0.2161 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.1193 | 0.6335 | 0.6335 |
Brugia malayi | Carboxylesterase family protein | 0.0909 | 0.3387 | 0.3387 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.1193 | 0.6335 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0763 | 0.1879 | 0.2966 |
Leishmania major | C-8 sterol isomerase-like protein | 0.1547 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1547 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.1193 | 0.6335 | 0.6335 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.1193 | 0.6335 | 1 |
Schistosoma mansoni | lipoxygenase | 0.1092 | 0.5286 | 0.8343 |
Echinococcus multilocularis | acetylcholinesterase | 0.0909 | 0.3387 | 0.5347 |
Brugia malayi | Carboxylesterase family protein | 0.0909 | 0.3387 | 0.3387 |
Loa Loa (eye worm) | hypothetical protein | 0.0909 | 0.3387 | 0.3387 |
Echinococcus granulosus | acetylcholinesterase | 0.0909 | 0.3387 | 0.5347 |
Echinococcus granulosus | carboxylesterase 5A | 0.0909 | 0.3387 | 0.5347 |
Loa Loa (eye worm) | hypothetical protein | 0.1547 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0909 | 0.3387 | 0.5347 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.1092 | 0.5286 | 0.8343 |
Loa Loa (eye worm) | carboxylesterase | 0.0909 | 0.3387 | 0.3387 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0909 | 0.3387 | 0.5347 |
Loa Loa (eye worm) | hypothetical protein | 0.0909 | 0.3387 | 0.3387 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.