Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3767 | 0.7619 | 0.7469 |
Onchocerca volvulus | 0.1521 | 0.1723 | 0.0279 | |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.2144 | 0.3358 | 0.3358 |
Echinococcus multilocularis | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.1521 | 0.1723 | 0.188 |
Loa Loa (eye worm) | hypothetical protein | 0.129 | 0.1117 | 0.1117 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Schistosoma mansoni | bile acid beta-glucosidase-related | 0.3767 | 0.7619 | 0.7469 |
Giardia lamblia | Ceramide glucosyltransferase | 0.1957 | 0.2869 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.0873 | 0.0023 | 0.5 |
Onchocerca volvulus | Ceramide glucosyltransferase homolog | 0.4318 | 0.9063 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Echinococcus granulosus | bile acid beta glucosidase | 0.3767 | 0.7619 | 0.8403 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus granulosus | non lysosomal glucosylceramidase | 0.3767 | 0.7619 | 0.8403 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.0873 | 0.0023 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.0873 | 0.0023 | 0.5 |
Schistosoma mansoni | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.3067 | 0.5781 | 0.5653 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.0873 | 0.0023 | 0.5 |
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.4674 | 1 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.1521 | 0.1723 | 0.188 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3232 | 0.6215 | 0.1027 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.3232 | 0.6215 | 0.1027 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.0873 | 0.0023 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.2144 | 0.3358 | 0.1975 |
Loa Loa (eye worm) | hypothetical protein | 0.2543 | 0.4406 | 0.4406 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1095 | 0.0606 | 0.0606 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.0873 | 0.0023 | 0.5 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.4674 | 1 | 1 |
Echinococcus granulosus | ceramide glucosyltransferase | 0.4318 | 0.9063 | 1 |
Echinococcus multilocularis | bile acid beta glucosidase | 0.3767 | 0.7619 | 0.8403 |
Loa Loa (eye worm) | ceramide glucosyltransferase | 0.4318 | 0.9063 | 0.9063 |
Brugia malayi | Ceramide glucosyltransferase | 0.4318 | 0.9063 | 0.8868 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.2144 | 0.3358 | 0.3689 |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.0873 | 0.0023 | 0.5 |
Echinococcus multilocularis | non lysosomal glucosylceramidase | 0.3767 | 0.7619 | 0.8403 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.