Detailed information for compound 826877

Basic information

Technical information
  • TDR Targets ID: 826877
  • Name: N-(1,2-benzoxazol-3-yl)-3-methylbutanamide
  • MW: 218.252 | Formula: C12H14N2O2
  • H donors: 1 H acceptors: 2 LogP: 2.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC(=O)Nc1noc2c1cccc2)C
  • InChi: 1S/C12H14N2O2/c1-8(2)7-11(15)13-12-9-5-3-4-6-10(9)16-14-12/h3-6,8H,7H2,1-2H3,(H,13,14,15)
  • InChiKey: BXRJDJPZFJJBJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(1,2-benzoxazol-3-yl)-3-methyl-butanamide
  • N-indoxazen-3-yl-3-methyl-butyramide
  • STK245379

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0724 0.2581 0.5
Loa Loa (eye worm) AGC/PKA protein kinase 0.0724 0.2581 0.2549
Loa Loa (eye worm) hypothetical protein 0.0384 0.1306 0.127
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Schistosoma mansoni serine/threonine protein kinase 0.0724 0.2581 0.2684
Echinococcus granulosus rho-associated protein kinase 1 0.0878 0.3157 0.3283
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0724 0.2581 0.5
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0724 0.2581 0.1466
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0724 0.2581 0.5
Echinococcus multilocularis microtubule associated serine:threonine protein 0.0046 0.0042 0.0044
Schistosoma mansoni protein kinase 0.2602 0.9616 1
Leishmania major protein kinase A catalytic subunit isoform 1 0.0724 0.2581 0.5
Trichomonas vaginalis AGC family protein kinase 0.0724 0.2581 0.5
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Schistosoma mansoni serine/threonine protein kinase 0.0724 0.2581 0.2684
Echinococcus granulosus peripheral plasma membrane protein CASK 0.0046 0.0042 0.0044
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0724 0.2581 0.5
Onchocerca volvulus 0.0865 0.311 0.9849
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.2705 1 1
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0724 0.2581 0.5
Onchocerca volvulus 0.0384 0.1306 0.4059
Leishmania major protein kinase A catalytic subunit 0.0724 0.2581 0.5
Echinococcus multilocularis dual specificity testis specific protein kinase 0.2602 0.9616 1
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0724 0.2581 0.5
Schistosoma mansoni protein kinase 0.2602 0.9616 1
Loa Loa (eye worm) hypothetical protein 0.0724 0.2581 0.2549
Schistosoma mansoni serine/threonine protein kinase 0.0878 0.3157 0.3283
Echinococcus granulosus dual specificity testis-specific protein kinase 0.2602 0.9616 1
Echinococcus multilocularis PKC activated phosphatase 1 inhibitor 0.0384 0.1306 0.1359
Echinococcus granulosus PKC activated phosphatase 1 inhibitor 0.0384 0.1306 0.1359
Toxoplasma gondii AGC kinase 0.0724 0.2581 0.5
Onchocerca volvulus 0.0878 0.3157 1
Schistosoma mansoni serine/threonine protein kinase 0.0724 0.2581 0.2684
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0724 0.2581 0.5
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0724 0.2581 0.5
Toxoplasma gondii AGC kinase 0.0724 0.2581 0.5
Giardia lamblia Kinase, AGC PKA 0.0724 0.2581 0.5
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0724 0.2581 0.5
Schistosoma mansoni MAGUK homolog 0.0046 0.0042 0.0044
Entamoeba histolytica PH domain containing protein kinase, putative 0.0724 0.2581 0.5
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Echinococcus multilocularis rho associated protein kinase 0.0878 0.3157 0.3283
Entamoeba histolytica PH domain containing protein kinase, putative 0.0724 0.2581 0.5
Echinococcus granulosus Microtubule-associated serine/threonine-protein kinase 0.0046 0.0042 0.0044
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0724 0.2581 0.5
Echinococcus multilocularis peripheral plasma membrane protein CASK 0.0046 0.0042 0.0044
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0711 0.2534 0.2635
Loa Loa (eye worm) AGC/PKA protein kinase 0.0724 0.2581 0.2549
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Schistosoma mansoni protein phosphatase 1 inhibitor potentiated by protein kinase C 0.0384 0.1306 0.1359
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0711 0.2534 0.2635
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0724 0.2581 0.2684
Leishmania major protein kinase A catalytic subunit isoform 2 0.0724 0.2581 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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