Detailed information for compound 827271

Basic information

Technical information
  • TDR Targets ID: 827271
  • Name: 3-[[2-(4-methoxyphenoxy)acetyl]amino]-N-(3-me thoxyphenyl)-1-benzofuran-2-carboxamide
  • MW: 446.452 | Formula: C25H22N2O6
  • H donors: 2 H acceptors: 2 LogP: 4.86 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCC(=O)Nc1c(oc2c1cccc2)C(=O)Nc1cccc(c1)OC
  • InChi: 1S/C25H22N2O6/c1-30-17-10-12-18(13-11-17)32-15-22(28)27-23-20-8-3-4-9-21(20)33-24(23)25(29)26-16-6-5-7-19(14-16)31-2/h3-14H,15H2,1-2H3,(H,26,29)(H,27,28)
  • InChiKey: STDOOGGDHJFEQF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[2-(4-methoxyphenoxy)acetyl]amino]-N-(3-methoxyphenyl)benzofuran-2-carboxamide
  • 3-[[2-(4-methoxyphenoxy)-1-oxoethyl]amino]-N-(3-methoxyphenyl)-2-benzofurancarboxamide
  • 3-[2-(4-methoxyphenoxy)ethanoylamino]-N-(3-methoxyphenyl)-1-benzofuran-2-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 1 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.005 0.3271 0.3271
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0087 0.6542 0.6542
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0087 0.6542 0.6542
Entamoeba histolytica prolyl oligopeptidase family protein 0.0013 0 0.5
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0087 0.6542 0.6542
Trypanosoma brucei prolyl oligopeptidase, putative 0.005 0.3271 0.3271
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0087 0.6542 0.6542
Entamoeba histolytica prolyl oligopeptidase family protein 0.0013 0 0.5
Trypanosoma brucei prolyl endopeptidase 0.0126 1 1
Trypanosoma cruzi prolyl endopeptidase 0.0126 1 1
Trypanosoma cruzi oligopeptidase b 0.005 0.3271 0.3271
Trypanosoma brucei oligopeptidase b 0.005 0.3271 0.3271
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.005 0.3271 0.3271
Giardia lamblia Alanyl dipeptidyl peptidase 0.0013 0 0.5
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.005 0.3271 0.3271
Loa Loa (eye worm) hypothetical protein 0.0087 0.6542 0.6542
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0087 0.6542 0.6542
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.005 0.3271 0.5
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0087 0.6542 0.6542
Giardia lamblia Alanyl dipeptidyl peptidase 0.0013 0 0.5
Plasmodium vivax hypothetical protein, conserved 0.0013 0 0.5
Onchocerca volvulus Prolyl endopeptidase homolog 0.0126 1 1
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0013 0 0.5
Leishmania major oligopeptidase b 0.005 0.3271 0.3271
Loa Loa (eye worm) hypothetical protein 0.0126 1 1
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.6542 0.6542
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0013 0 0.5
Echinococcus granulosus prolyl endopeptidase 0.0126 1 1
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0087 0.6542 0.6542
Toxoplasma gondii prolyl endopeptidase 0.0126 1 1
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0013 0 0.5
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.005 0.3271 0.5
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.005 0.3271 0.3271
Entamoeba histolytica hypothetical protein, conserved 0.0013 0 0.5
Trypanosoma cruzi oligopeptidase b 0.005 0.3271 0.3271
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0126 1 1
Entamoeba histolytica prolyl oligopeptidase family protein 0.0013 0 0.5
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0013 0 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0013 0 0.5
Onchocerca volvulus Putative nachr subunit 0.0087 0.6542 0.6542
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0126 1 1
Plasmodium falciparum peptidase, putative 0.0013 0 0.5
Echinococcus multilocularis prolyl endopeptidase 0.0126 1 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0113 0.8828 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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