Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0.1062 | 0.5 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.533 | 0.4775 |
Brugia malayi | hypothetical protein | 0.0025 | 0.3135 | 0.3135 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0.1062 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0019 | 0.1062 | 0.1062 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0.1062 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0.1062 | 0.5 |
Echinococcus granulosus | dna polymerase eta | 0.0044 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.533 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.3135 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.533 | 0.4775 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0044 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0.1062 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0.1062 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1062 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0044 | 1 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0044 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.3135 | 0.2319 |
Schistosoma mansoni | DNA polymerase eta | 0.0044 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.3135 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.3135 | 0.2319 |
Leishmania major | DNA polymerase eta, putative | 0.0044 | 1 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0.1062 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.