Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0187 | 0.1715 | 0.286 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0169 | 0.1515 | 0.146 |
Giardia lamblia | Kinase, STE STE20 | 0.0235 | 0.2263 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0153 | 0.1333 | 0.2198 |
Schistosoma mansoni | glutamate receptor NMDA | 0.036 | 0.3693 | 0.6259 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0911 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0911 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0187 | 0.1715 | 0.286 |
Schistosoma mansoni | hypothetical protein | 0.0063 | 0.0295 | 0.0326 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0042 | 0.0064 | 0.0064 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0187 | 0.1715 | 0.286 |
Schistosoma mansoni | protein kinase | 0.0235 | 0.2263 | 0.3762 |
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0063 | 0.0295 | 0.0401 |
Schistosoma mansoni | glutamate receptor kainate | 0.0169 | 0.1515 | 0.2455 |
Brugia malayi | Dual specificity mitogen-activated protein kinase kinase mek-2 | 0.0235 | 0.2263 | 0.2213 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.036 | 0.3693 | 0.6288 |
Schistosoma mansoni | glutamate receptor kainate | 0.0169 | 0.1515 | 0.2455 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0277 | 0.2752 | 0.4616 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0153 | 0.1333 | 0.2198 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0187 | 0.1715 | 0.286 |
Trichomonas vaginalis | STE family protein kinase | 0.0235 | 0.2263 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0547 | 0.5836 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0911 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0187 | 0.1715 | 0.286 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.036 | 0.3693 | 0.6288 |
Echinococcus granulosus | glutamate receptor 2 | 0.0124 | 0.0999 | 0.1619 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0547 | 0.5836 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0187 | 0.1715 | 0.286 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0169 | 0.1515 | 0.2455 |
Loa Loa (eye worm) | hypothetical protein | 0.0911 | 1 | 1 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0547 | 0.5836 | 0.5809 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0187 | 0.1715 | 0.286 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0187 | 0.1715 | 0.286 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0547 | 0.5836 | 1 |
Echinococcus granulosus | Ribosomal protein S1 RNA binding domain | 0.0063 | 0.0295 | 0.0401 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0547 | 0.5836 | 0.5836 |
Echinococcus multilocularis | glutamate receptor subunit protein glur | 0.0063 | 0.0295 | 0.0401 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0108 | 0.0817 | 0.1304 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0187 | 0.1715 | 0.286 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0108 | 0.0817 | 0.1304 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0091 | 0.0616 | 0.0957 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0169 | 0.1515 | 0.2513 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0091 | 0.0616 | 0.0957 |
Loa Loa (eye worm) | hypothetical protein | 0.0466 | 0.4905 | 0.4905 |
Echinococcus multilocularis | NMDA receptor | 0.0063 | 0.0295 | 0.0401 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0169 | 0.1515 | 0.1515 |
Echinococcus granulosus | glutamate receptor subunit protein glur | 0.0063 | 0.0295 | 0.0401 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0063 | 0.0295 | 0.0401 |
Schistosoma mansoni | glutamate receptor kainate | 0.0169 | 0.1515 | 0.2455 |
Loa Loa (eye worm) | STE/STE7/MEK1 protein kinase | 0.0235 | 0.2263 | 0.2263 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0169 | 0.1515 | 0.2455 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0063 | 0.0295 | 0.0401 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0169 | 0.1515 | 0.2455 |
Trichomonas vaginalis | STE family protein kinase | 0.0235 | 0.2263 | 1 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0169 | 0.1515 | 0.146 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0169 | 0.1515 | 0.1515 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0547 | 0.5836 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0063 | 0.0295 | 0.0401 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0187 | 0.1715 | 0.286 |
Trichomonas vaginalis | STE family protein kinase | 0.0235 | 0.2263 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0235 | 0.2263 | 0.381 |
Echinococcus multilocularis | Ribosomal protein S1, RNA binding domain | 0.0063 | 0.0295 | 0.0401 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0235 | 0.2263 | 0.381 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0124 | 0.0999 | 0.1619 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.