Detailed information for compound 827796

Basic information

Technical information
  • TDR Targets ID: 827796
  • Name: 3-(4-fluorobenzoyl)-1-[(2-fluorophenyl)methyl ]-6-methylquinolin-4-one
  • MW: 389.394 | Formula: C24H17F2NO2
  • H donors: 0 H acceptors: 2 LogP: 5.31 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc2c(c1)c(=O)c(cn2Cc1ccccc1F)C(=O)c1ccc(cc1)F
  • InChi: 1S/C24H17F2NO2/c1-15-6-11-22-19(12-15)24(29)20(23(28)16-7-9-18(25)10-8-16)14-27(22)13-17-4-2-3-5-21(17)26/h2-12,14H,13H2,1H3
  • InChiKey: CPPSFMJKXNEALD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(4-fluorobenzoyl)-1-[(2-fluorophenyl)methyl]-6-methyl-quinolin-4-one
  • 1-[(2-fluorophenyl)methyl]-3-[(4-fluorophenyl)-oxomethyl]-6-methyl-4-quinolinone
  • 3-(4-fluorobenzoyl)-1-(2-fluorobenzyl)-6-methyl-4-quinolone
  • 3-(4-fluorophenyl)carbonyl-1-[(2-fluorophenyl)methyl]-6-methyl-quinolin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hexose transporter, putative 0.0021 0.0142 0.1383
Loa Loa (eye worm) hypothetical protein 0.0037 0.0449 0.2038
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.01 0.0505
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0075 0.0199
Plasmodium falciparum calcium-dependent protein kinase 4 0.0037 0.0459 0.0404
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0308 0.0245
Echinococcus granulosus synaptic vesicle 2 protein 0.0017 0.0075 0.0075
Trichomonas vaginalis conserved hypothetical protein 0.0121 0.2066 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0449 0.0449
Onchocerca volvulus 0.0017 0.0075 0.5
Giardia lamblia Prolyl-tRNA synthetase 0.0036 0.0444 1
Echinococcus multilocularis calcium dependent protein kinase 0.0035 0.0415 0.0415
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0308 0.0375
Trichomonas vaginalis CAMK family protein kinase 0.0037 0.0459 0.1927
Schistosoma mansoni protein kinase 0.0037 0.0459 0.2221
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Echinococcus multilocularis GPCR, family 2 0.0037 0.0449 0.0449
Brugia malayi Isocitrate dehydrogenase 0.0018 0.01 0.0123
Schistosoma mansoni hypothetical protein 0.0037 0.0449 0.2172
Loa Loa (eye worm) hypothetical protein 0.0037 0.0459 0.2088
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0449 0.2038
Plasmodium falciparum calcium-dependent protein kinase 1 0.0037 0.0459 0.0404
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.01 0.0039
Leishmania major hypothetical protein, conserved 0.0029 0.0308 0.481
Brugia malayi lysyl-tRNA synthetase 0.0027 0.0266 0.0961
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0037 0.0459 0.2088
Echinococcus granulosus GPCR family 2 0.0037 0.0449 0.0449
Schistosoma mansoni glucose transport protein 0.0121 0.2066 1
Schistosoma mansoni serine/threonine protein kinase 0.0037 0.0459 0.2221
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0036 0.0444 0.0444
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Onchocerca volvulus 0.0017 0.0075 0.5
Echinococcus granulosus solute carrier family 22 0.0017 0.0075 0.0075
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0266 1
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0027 0.0266 0.395
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.01 0.032
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Onchocerca volvulus 0.0017 0.0075 0.5
Echinococcus granulosus solute carrier family 22 0.0017 0.0075 0.0075
Plasmodium falciparum calcium-dependent protein kinase 5 0.0037 0.0459 0.0404
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.01 0.2159
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0468 0.1973
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0468 0.1973
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Plasmodium falciparum lysine--tRNA ligase 0.0027 0.0266 0.0201
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.01 0.0505
Onchocerca volvulus 0.0017 0.0075 0.5
Onchocerca volvulus 0.0017 0.0075 0.5
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0017 0.0075 0.0364
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.056 1
Brugia malayi hypothetical protein 0.0019 0.011 0.0176
Entamoeba histolytica protein kinase, putative 0.0037 0.0459 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0468 0.8107
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0308 0.0245
Chlamydia trachomatis lysine--tRNA ligase 0.0027 0.0266 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0079 0.126 0.5952
Echinococcus granulosus solute carrier family 22 0.0017 0.0075 0.0075
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Onchocerca volvulus 0.0017 0.0075 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0444 0.2017
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0036 0.0444 0.0444
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0037 0.0459 0.0617
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0036 0.0444 1
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Leishmania major glucose transporter, lmgt1 0.0038 0.0468 0.8107
Onchocerca volvulus 0.0017 0.0075 0.5
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Loa Loa (eye worm) sugar transporter 0.0017 0.0075 0.0199
Schistosoma mansoni glucose transporter 0.0017 0.0075 0.0364
Echinococcus granulosus solute carrier family 22 0.0017 0.0075 0.0075
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0115 0.1959 0.9476
Onchocerca volvulus 0.0017 0.0075 0.5
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Echinococcus multilocularis neuropeptide receptor A26 0.0535 1 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Onchocerca volvulus 0.0017 0.0075 0.5
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Loa Loa (eye worm) sugar transporter 0.0121 0.2066 1
Onchocerca volvulus 0.0017 0.0075 0.5
Echinococcus multilocularis solute carrier family 22 0.0017 0.0075 0.0075
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0037 0.0459 0.0404
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.056 1
Leishmania major glucose transporter, lmgt3 0.0038 0.0468 0.8107
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0024 0.0203 0.0641
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.01 0.0505
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0449 0.0449
Trypanosoma brucei glucose transporter 1E 0.0038 0.0468 0.8107
Schistosoma mansoni hypothetical protein 0.0037 0.0449 0.2172
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Schistosoma mansoni hypothetical protein 0.0037 0.0449 0.2172
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0042 0.056 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0121 0.2066 0.2066
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Giardia lamblia Lysyl-tRNA synthetase 0.0027 0.0266 0.5182
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.01 0.0039
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0023 0.0189 1
Schistosoma mansoni protein kinase 0.0037 0.0459 0.2221
Schistosoma mansoni sugar transporter 0.0017 0.0075 0.0364
Schistosoma mansoni glucose transport protein 0.0121 0.2066 1
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0027 0.0266 0.0961
Echinococcus granulosus calcium dependent protein kinase 0.0035 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Schistosoma mansoni sugar transporter 0.0017 0.0075 0.0364
Trypanosoma brucei glucose transporter 2A 0.0038 0.0468 0.8107
Echinococcus multilocularis solute carrier family 22 0.0017 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0266 0.129
Schistosoma mansoni lysyl-tRNA synthetase 0.0027 0.0266 0.129
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0036 0.0444 0.1855
Echinococcus multilocularis solute carrier family 22 0.0017 0.0075 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Plasmodium falciparum protein kinase 7 0.0342 0.6295 0.6542
Echinococcus multilocularis synaptic vesicle 2 protein 0.0017 0.0075 0.0075
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.01 0.0482
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0017 0.0075 0.5
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0308 0.481
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0027 0.0266 1
Plasmodium vivax hexose transporter 0.0121 0.2066 0.2094
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.056 1
Toxoplasma gondii protein kinase, putative 0.0342 0.6295 1
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0037 0.0459 0.1927
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0449 0.0449
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.01 0.01
Entamoeba histolytica protein kinase, putative 0.0037 0.0459 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.01 0.0026
Brugia malayi isocitrate dehydrogenase 0.0018 0.01 0.0123
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0308 0.481
Leishmania major protein kinase, putative 0.0037 0.0459 0.7919
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0036 0.0444 0.9253
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Plasmodium vivax proline--tRNA ligase, putative 0.0042 0.056 0.051
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0037 0.0459 0.7919
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0468 0.1973
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0449 0.1876
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0468 0.1973
Toxoplasma gondii lysine-tRNA ligase 0.0027 0.0266 0.0308
Brugia malayi Sugar transporter family protein 0.0121 0.2066 1
Plasmodium falciparum protein kinase 6 0.0513 0.9582 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Leishmania major lysyl-tRNA synthetase, putative 0.0027 0.0266 0.395
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0037 0.0459 0.0459
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Leishmania major glucose transporter/membrane transporter D2, putative 0.0038 0.0468 0.8107
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0023 0.0189 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0308 0.481
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Schistosoma mansoni sugar transporter 0.0017 0.0075 0.0364
Echinococcus multilocularis General substrate transporter 0.0104 0.174 0.174
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0449 0.0449
Loa Loa (eye worm) major facilitator superfamily transporter 0.0017 0.0075 0.0199
Loa Loa (eye worm) hypothetical protein 0.0115 0.1959 0.9476
Schistosoma mansoni hypothetical protein 0.0037 0.0449 0.2172
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0449 0.1876
Plasmodium falciparum calcium-dependent protein kinase 2 0.0037 0.0459 0.0404
Brugia malayi Calcitonin receptor-like protein seb-1 0.0115 0.1959 0.9465
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0468 0.8107
Loa Loa (eye worm) hypothetical protein 0.0036 0.0444 0.2017
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0037 0.0459 0.0617
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0042 0.056 1
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0444 0.2151
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0037 0.0459 0.0617
Schistosoma mansoni hypothetical protein 0.0079 0.126 0.61
Plasmodium vivax calcium-dependent protein kinase, putative 0.0037 0.0459 0.0404
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0468 0.1973
Plasmodium falciparum mitogen-activated protein kinase 2 0.0195 0.3493 0.3595
Echinococcus granulosus neuropeptide receptor A26 0.0535 1 1
Trichomonas vaginalis sugar transporter, putative 0.0038 0.0468 0.1973
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0468 0.8107
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.01 0.01
Onchocerca volvulus 0.0017 0.0075 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0115 0.1959 0.9465
Plasmodium vivax CDK-related protein kinase 6, putative 0.0513 0.9582 1
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0468 0.8107
Onchocerca volvulus 0.0017 0.0075 0.5
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0037 0.0459 0.0404
Toxoplasma gondii facilitative glucose transporter GT1 0.0121 0.2066 0.3201
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0195 0.3493 0.3595
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0195 0.3493 0.5495
Leishmania major glucose transporter, lmgt2 0.0038 0.0468 0.8107
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.01 0.0505
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0042 0.056 0.0779
Onchocerca volvulus 0.0017 0.0075 0.5
Loa Loa (eye worm) hypothetical protein 0.0079 0.126 0.6033
Plasmodium vivax lysine--tRNA ligase, putative 0.0027 0.0266 0.0201
Echinococcus multilocularis lysyl tRNA synthetase 0.0027 0.0266 0.0266
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Echinococcus granulosus General substrate transporter 0.0104 0.174 0.174
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0308 0.0245
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0036 0.0444 0.1855
Onchocerca volvulus Putative transporter 0.0017 0.0075 0.5
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0036 0.0444 0.2151
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0027 0.0266 0.3046
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.01 0.0505
Trypanosoma brucei THT1 - hexose transporter, putative 0.0038 0.0468 0.8107
Brugia malayi Cam kinase protein 1 0.0037 0.0459 0.1927
Plasmodium falciparum hexose transporter 0.0121 0.2066 0.2094
Echinococcus granulosus Sugar transporter ERD6 protein 0.0017 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0029 0.0308 0.1346
Onchocerca volvulus 0.0017 0.0075 0.5
Schistosoma mansoni hypothetical protein 0.0121 0.2066 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0027 0.0266 0.395
Trichomonas vaginalis glucose transporter, putative 0.0038 0.0468 0.1973
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0037 0.0459 0.0459
Schistosoma mansoni protein kinase 0.0037 0.0459 0.2221
Trypanosoma cruzi hexose transporter, putative 0.0038 0.0468 0.8107
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0017 0.0075 0.0075
Onchocerca volvulus 0.0017 0.0075 0.5
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0036 0.0444 0.1855
Schistosoma mansoni glucose transport protein 0.0121 0.2066 1
Brugia malayi hypothetical protein 0.0029 0.0308 0.117
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.01 0.0026
Echinococcus multilocularis solute carrier family 22 0.0017 0.0075 0.0075
Schistosoma mansoni sugar transporter 0.0017 0.0075 0.0364
Loa Loa (eye worm) hypothetical protein 0.0029 0.0314 0.1375
Echinococcus granulosus lysyl tRNA synthetase 0.0027 0.0266 0.0266
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0037 0.0459 0.0404
Onchocerca volvulus 0.0017 0.0075 0.5
Plasmodium falciparum calcium-dependent protein kinase 3 0.0037 0.0459 0.0404
Plasmodium falciparum proline--tRNA ligase 0.0042 0.056 0.051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0266 0.1141
Loa Loa (eye worm) hypothetical protein 0.0017 0.0075 0.0199
Echinococcus multilocularis neuropeptide s receptor 0.0535 1 1
Trypanosoma cruzi hexose transporter 0.0038 0.0468 0.8107
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0121 0.2066 0.2066
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0037 0.0459 0.2088
Trypanosoma brucei glucose transporter, putative 0.0038 0.0468 0.8107

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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