Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0923 | 0.1463 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3361 | 0.4997 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0923 | 0.1463 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0923 | 0.0184 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0923 | 1 |
Echinococcus multilocularis | geminin | 0.0167 | 0.5725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0833 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0923 | 0.0858 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.0923 | 0.5 |
Echinococcus granulosus | geminin | 0.0167 | 0.5725 | 1 |
Brugia malayi | hypothetical protein | 0.003 | 0.0418 | 0.0663 |
Brugia malayi | hypothetical protein | 0.0182 | 0.6308 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0923 | 0.0858 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0923 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0418 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0923 | 0.0858 |
Brugia malayi | hypothetical protein | 0.0106 | 0.3361 | 0.5329 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1571 | 0.249 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.0923 | 0.5 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0.0418 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.4824 | 0.748 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0923 | 0.1463 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0923 | 0.0858 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0923 | 0.0858 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1571 | 0.249 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.0923 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.0923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0923 | 0.0858 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0833 | 0.1321 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0923 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0923 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0923 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.4824 | 0.748 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0923 | 0.0858 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1571 | 0.1957 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5725 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.3361 | 0.4997 |
Loa Loa (eye worm) | hypothetical protein | 0.0182 | 0.6308 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.0923 | 0.5 |
Schistosoma mansoni | eyes absent homolog | 0.0106 | 0.3361 | 0.5168 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0923 | 0.0858 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0923 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0923 | 1 |
Onchocerca volvulus | 0.0182 | 0.6308 | 1 | |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.0923 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0923 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0043 | 0.0923 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 0.5725 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.4824 | 0.7647 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.0923 | 0.0184 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0043 | 0.0923 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1571 | 0.1957 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0923 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.0923 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0043 | 0.0923 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0923 | 0.1463 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.8184 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 15.8489 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 44.6684 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.