Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 1 | 1 |
Echinococcus multilocularis | Smad4 | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Schistosoma mansoni | tyrosinase precursor | 0.0176 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.8077 | 0.8077 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0176 | 1 | 1 |
Echinococcus granulosus | smad | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.0176 | 1 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.8077 | 0.8077 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0176 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.8077 | 0.8077 |
Schistosoma mansoni | tyrosinase precursor | 0.0176 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0176 | 1 | 1 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.001 | 0 | 0.5 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.001 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0176 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0176 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.001 | 0 | 0.5 |
Echinococcus granulosus | Smad4 | 0.001 | 0 | 0.5 |
Echinococcus multilocularis | smad | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.0176 | 1 | 0.5 | |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.