Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | sterol regulatory element binding protein | 0.0501 | 0.3413 | 0.3413 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1218 | 1 | 0.5 |
Brugia malayi | CHE-14 protein | 0.0501 | 0.3413 | 0.3413 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1218 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0571 | 0.4056 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1218 | 1 | 0.5 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0501 | 0.3413 | 0.3413 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0501 | 0.3413 | 0.3413 |
Onchocerca volvulus | Putative nachr subunit | 0.013 | 0 | 0.5 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0501 | 0.3413 | 0.3413 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0571 | 0.4056 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0571 | 0.4056 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1218 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 1 | 1 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1218 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1218 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.3413 | 0.3413 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0501 | 0.3413 | 0.3413 |
Echinococcus multilocularis | protein dispatched 1 | 0.0501 | 0.3413 | 0.3413 |
Echinococcus multilocularis | protein patched | 0.0501 | 0.3413 | 0.3413 |
Schistosoma mansoni | patched 1 | 0.0501 | 0.3413 | 0.3413 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0571 | 0.4056 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0501 | 0.3413 | 0.3413 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1218 | 1 | 1 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1218 | 1 | 0.5 |
Onchocerca volvulus | 0.013 | 0 | 0.5 | |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0501 | 0.3413 | 0.3413 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.