Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0323 | 0.059 |
Brugia malayi | valosin containing protein | 0.0235 | 0.547 | 1 |
Brugia malayi | transitional endoplasmic reticulum ATPase TER94, putative | 0.0166 | 0.3576 | 0.632 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0323 | 0.059 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.5412 | 0.9893 |
Brugia malayi | hypothetical protein | 0.0233 | 0.5412 | 0.9886 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0047 | 0.0323 | 0.5 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0323 | 0.0576 |
Trichomonas vaginalis | spermatogenesis associated factor, putative | 0.0401 | 1 | 1 |
Echinococcus multilocularis | transitional endoplasmic reticulum atpase | 0.0401 | 1 | 1 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0047 | 0.0323 | 0.0576 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0047 | 0.0323 | 0.0576 |
Loa Loa (eye worm) | vesicle-fusing ATPase | 0.0235 | 0.547 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0323 | 0.0576 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.5412 | 0.2857 |
Trypanosoma brucei | Valosin-containing protein | 0.038 | 0.9436 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0047 | 0.0323 | 0.0576 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0047 | 0.0323 | 0.0576 |
Toxoplasma gondii | cell division protein CDC48CY | 0.0401 | 1 | 1 |
Onchocerca volvulus | 0.0048 | 0.0345 | 0.0023 | |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0047 | 0.0323 | 0.0576 |
Toxoplasma gondii | cell division protein CDC48AP | 0.024 | 0.5602 | 0.0000097958 |
Mycobacterium tuberculosis | Putative conserved ATPase | 0.024 | 0.5602 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.038 | 0.9436 | 0.9416 |
Leishmania major | Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog | 0.038 | 0.9436 | 1 |
Entamoeba histolytica | cdc48-like protein, putative | 0.038 | 0.9436 | 1 |
Onchocerca volvulus | Transitional endoplasmic reticulum ATPase homolog | 0.0401 | 1 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0401 | 1 | 1 |
Trypanosoma cruzi | Valosin-containing protein, putative | 0.038 | 0.9436 | 0.5 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0047 | 0.0323 | 0.5 |
Plasmodium falciparum | cell division cycle protein 48 homologue, putative | 0.038 | 0.9436 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0047 | 0.0323 | 0.0576 |
Loa Loa (eye worm) | VCP protein | 0.0166 | 0.3576 | 0.6537 |
Giardia lamblia | AAA family ATPase | 0.024 | 0.5602 | 0.5 |
Entamoeba histolytica | transitional endoplasmic reticulum ATPase, putative | 0.038 | 0.9436 | 1 |
Schistosoma mansoni | cell division control protein 48 aaa family protein | 0.0166 | 0.3576 | 0.3347 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0047 | 0.0323 | 0.0576 |
Mycobacterium ulcerans | ATPase | 0.024 | 0.5602 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.547 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0323 | 0.059 |
Plasmodium vivax | cell division cycle ATPase, putative | 0.0145 | 0.3012 | 0.3192 |
Plasmodium vivax | cell division cycle protein 48 homologue, putative | 0.038 | 0.9436 | 1 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0345 | 0.0043 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0047 | 0.0323 | 0.0576 |
Brugia malayi | vesicle-fusing ATPase | 0.0235 | 0.547 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.