TDR Targets

Basic information

Technical information

TDR Targets ID: 830874
Name: 3-[6-(4-ethylpiperazin-1-yl)-[1,2,4]triazolo[ 5,4-f]pyridazin-3-yl]-N-(4-methylphenyl)propa namide
MW: 393.485 | Formula: C21H27N7O
H donors: 1 H acceptors: 4 LogP: 1.84 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: CCN1CCN(CC1)c1ccc2n(n1)c(CCC(=O)Nc1ccc(cc1)C)nn2
InChi: 1S/C21H27N7O/c1-3-26-12-14-27(15-13-26)20-9-8-18-23-24-19(28(18)25-20)10-11-21(29)22-17-6-4-16(2)5-7-17/h4-9H,3,10-15H2,1-2H3,(H,22,29)
InChiKey: UOOMZWSUWJQJNO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-[6-(4-ethyl-1-piperazinyl)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]-N-(4-methylphenyl)propanamide
3-[6-(4-ethylpiperazin-1-yl)-[1,2,4]triazolo[5,4-f]pyridazin-3-yl]-N-(4-methylphenyl)propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0213	0.5124	0.5106
Loa Loa (eye worm)	hypothetical protein	0.0102	0.1556	0.1755
Echinococcus multilocularis	protein kinase c epsilon type	0.0165	0.3588	0.3564
Loa Loa (eye worm)	hypothetical protein	0.0154	0.3227	0.3685
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0527	1
Trypanosoma brucei	monoglyceride lipase, putative	0.007	0.0527	1
Schistosoma mansoni	amidase	0.0102	0.1556	0.2986
Trypanosoma brucei	monoglyceride lipase, putative	0.007	0.0527	1
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.007	0.0527	1
Plasmodium falciparum	lysophospholipase, putative	0.007	0.0527	0.5
Brugia malayi	protein kinase C II.	0.0165	0.3588	1
Onchocerca volvulus		0.027	0.6952	0.5
Echinococcus multilocularis	RNA directed DNA polymerase	0.0115	0.1996	0.1966
Trypanosoma cruzi	monoglyceride lipase, putative	0.007	0.0527	0.5
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0165	0.3588	0.4103
Schistosoma mansoni	serine/threonine protein kinase	0.0213	0.5124	1
Mycobacterium tuberculosis	Possible lysophospholipase	0.007	0.0527	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0165	0.3588	0.6981
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0102	0.1556	0.1524
Loa Loa (eye worm)	hypothetical protein	0.0324	0.8692	1
Schistosoma mansoni	serine/threonine protein kinase	0.0213	0.5124	1
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0527	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0069	0.0499	0.9413
Loa Loa (eye worm)	hypothetical protein	0.027	0.6952	0.7989
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Toxoplasma gondii	AGC kinase	0.0054	0.0038	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0527	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0102	0.1556	0.1524
Echinococcus granulosus	protein kinase c iota type	0.0093	0.1268	0.1235
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0115	0.1996	0.1966
Loa Loa (eye worm)	hypothetical protein	0.0308	0.8182	0.9411
Mycobacterium ulcerans	lysophospholipase	0.007	0.0527	0.5
Schistosoma mansoni	atypical protein kinase C	0.0093	0.1268	0.2419
Plasmodium falciparum	lysophospholipase, putative	0.007	0.0527	0.5
Loa Loa (eye worm)	hypothetical protein	0.027	0.6952	0.7989
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Echinococcus multilocularis	protein kinase c iota type	0.0093	0.1268	0.1235
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Mycobacterium ulcerans	hypothetical protein	0.007	0.0527	0.5
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0527	1
Brugia malayi	amidase	0.0102	0.1556	0.4276
Echinococcus granulosus	protein kinase C gamma type	0.0174	0.3894	0.3871
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0102	0.1556	0.1524
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.007	0.0527	1
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Schistosoma mansoni	fatty-acid amide hydrolase	0.0102	0.1556	0.2986
Loa Loa (eye worm)	hypothetical protein	0.0115	0.1996	0.2264
Echinococcus granulosus	protein kinase c epsilon type	0.0165	0.3588	0.3564
Echinococcus multilocularis	serine threonine protein kinase	0.0174	0.3894	0.3871
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Echinococcus granulosus	serine:threonine protein kinase N2	0.0069	0.0499	0.0463
Plasmodium vivax	PST-A protein	0.007	0.0527	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0527	1
Loa Loa (eye worm)	hypothetical protein	0.027	0.6952	0.7989
Trichomonas vaginalis	conserved hypothetical protein	0.007	0.0527	1
Plasmodium falciparum	lysophospholipase, putative	0.007	0.0527	0.5
Echinococcus multilocularis	expressed protein	0.0365	1	1
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.007	0.0527	1
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Plasmodium falciparum	esterase, putative	0.007	0.0527	0.5
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.007	0.0527	0.5
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0121	0.2191	0.2489
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0102	0.1556	0.1524
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0122	0.2201	0.2172
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Echinococcus granulosus	RNA directed DNA polymerase	0.0115	0.1996	0.1966
Trichomonas vaginalis	AGC family protein kinase	0.0054	0.0038	0.0712
Leishmania major	monoglyceride lipase, putative	0.007	0.0527	0.5
Echinococcus granulosus	Protein kinase C brain isozyme	0.0213	0.5124	0.5106
Brugia malayi	Protein kinase c protein 2	0.016	0.3421	0.953
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.007	0.0527	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 830874